2011 Fiscal Year Final Research Report
Comprehensive study of hepatitis B virus genotypes and mutations involved in the pathogenesis
| Project/Area Number |
22790627
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
INOUE Jun 東北大学, 病院, 医員 (60455821)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 肝臓学 / ウイルス性肝炎 |
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| Research Abstract |
To investigate hepatitis B virus (HBV)genotypes and mutations that are involved in the pathogenesis, full-genome analysis of genotype B1/Bj HBV, which is known to occur fulminant hepatitis frequently, was performed. Interestingly, single nucleotide insertion/deletion that causes frameshift in the precore region was found frequently in fulminant hepatitis strains. Furthermore, amino acid 21 mutation in the core protein was also found frequently. In vitro studies clarified that HBV with these insertion/deletion/mutation showed high replication capacity. These findings might clarify a part of fulminant hepatitis pathogenesis.
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Research Products
(6 results)
