2011 Fiscal Year Final Research Report
The analysis of correlation between pancreatic fibrosis and pancreatic diabetes.
| Project/Area Number |
22790629
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 膵性糖尿病 / 膵線維化 / 膵星細胞 |
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| Research Abstract |
It remains unknown that pancreatic stellate cells (PSCs)play a role in the development of pancreatic diabetes. We examined the interaction between PSCs and pancreatic beta-cells. PSCs inhibited insulin expression and induced apoptosis of beta-cells, suggesting that PSCs might play a role in the development of pancreatic fibrosis and anti-fibrosis therapy targeting PSCs might be useful for the prevention of pancreatic diabetes.
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