2011 Fiscal Year Final Research Report
Chemoprevention for gastric carcinogenesis by inhibition of renin-angiotensin system
| Project/Area Number |
22790640
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 上部消化管学(食道、胃、十二指腸) |
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| Research Abstract |
Gastric mucosal AT1R and AT2R mRNAs/β-actin mRNA ratios were approximately zero in H. pylori uninfected animals throughout the 12-month observation period. On the other hand, both AT1R and AT2R mRNA ratios in animals treated with wild-type H. pylori gradually increased during the time course. The median MNCs infiltration score was significantly correlated with AT1R and AT2R levels. The cagA-and oipA-knockout strain induced significantly milder inflammation compared with the wild-type. AT1R and AT2R mRNA levels were significantly higher in gerbils that developed gastric ulcers than in gerbils without gastric ulcer, suggested that RAS inhibitors may have chemoprevention for gastric carcinogenesis.
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