2011 Fiscal Year Final Research Report
Roles of nardilysin and ADAM proteases in the regulation of gastric cancer cell growth.
| Project/Area Number |
22790641
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 上部消化管学(食道、胃、十二指腸) / 胃癌 |
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| Research Abstract |
Nardilysin(NRDc) has been reported to promote ectodomain shedding of the precursor forms of various growth factors in cooperation with ADAM proteins such as ADAM17. NRDc expression was frequently elevated in the cancer epithelium of gastric cancer tissues. After knockdown of NRDc expression, gastric cancer cell growth was suppressed. In gastric cancer cells, NRDc promotes ectodomain shedding of pro-TNF-alpha, leading to the upregulated transcription of various cytokines such as IL-6. As a result, NRDc maintains the expressions of growth-related genes via activated STAT3.
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[Journal Article] Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signaling via enhanced ectodomain shedding of TNF-alpha2012
Author(s)
Keitaro Kanda, Hideyuki Komekado, Tateo Sawabu, Shoko Ishizu, Yuki Nakanishi, Masato Nakatsuji, Reiko Akitake-Kawano, Mikiko Ohno, Yoshinori Hiraoka, Mayumi Kawada, Kenji Kawada, Yoshiharu Sakai, Kyoichi Matsumoto, Makoto Kunichika, Takeshi Kimura, Hiroshi Seno, Eiichiro Nishi, Tsutomu Chiba
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Journal Title
EMBO Molecular Medicine
Volume: vol.4
Pages: 396-411
DOI
Peer Reviewed
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