2011 Fiscal Year Final Research Report

Search for biomarkers against colorectal cancer by the mass spectrometry-based metabolome analysis

Research Project

Project/Area Number	22790645
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Gastroenterology
Research Institution	Kobe University
Principal Investigator	OKUNO Tatsuya 神戸大学, 医学部附属病院, 特定助教 (50464269)
Project Period (FY)	2010 – 2011
Keywords	メタボロミクス / バイオマーカー / 早期診断 / がん / 質量分析
Research Abstract	In the cells with pathological conditions, a variety of metabolites are produced via the secretion of disease-related proteins and the protein degradation by proteases. However, the comprehensive study on these disease-specific low-molecular weight metabolites has not obtained the good and interesting results yet because of various problems. Therefore, the experiments to comprehensively analyze the low-molecular weight metabolites derived from colorectal carcinomas was designed, and the novel cancer-specific biomarkers was searched. In addition, it was investigated whether the identified biomarkers can be actually used in the clinical practice.