2011 Fiscal Year Final Research Report
Development of the novel liver repair therapy with interaction between bone marrow stem cells and macrophages
| Project/Area Number |
22790647
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 肝再生 / 肝線維化 / 骨髄細胞 / マクロファージ |
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| Research Abstract |
Macrophages which are infiltrated into the liver after bone marrow stem cell transplantation to cirrhotic mice are mainly originated from recipients and stromal derived factor 1/ CXCR4 signaling is closely related to the migration of macrophages from bone marrow to the liver. And also, matrix metalloproteinase 9 expressed by macrophages can reduce collagen fiber in the liver. We will develop the novel liver repair therapy to improve hepatic fibrosis with interaction between bone marrow stem cells and macrophages.
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