2011 Fiscal Year Final Research Report
Involvement of renin-angiotensin system for the development of NASH
| Project/Area Number |
22790650
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kochi University |
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Principal Investigator |
HIROSE Akira 高知大学, 教育研究部・医療学系, 助教 (30457395)
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| Project Period (FY) |
2010 – 2011
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| Keywords | NASH |
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| Research Abstract |
We reported that renin-angiotensin system is important for progression of hepatic fibrosis in NASH. Angiotensin type 1 receptor blocker(ARB) attenuates progression of hepatic fibrosis in NASH by inhibition of angiotensin type 1 receptor(AT1) activity. We clarified, in this study, that attenuation of AT1 receptor activity by ARB was not related to the inhibition of mechanical activation of AT1 receptor unlike heart muscle cells, and inhibition of the signal transduction of AGE-RAGE system in hepatic stellate cells by ARB was central role for the attenuation of development of NASH.
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[Journal Article] A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet2011
Author(s)
Ogasawara M, Hirose A, Ono M, Aritake K, Nozaki Y, Takahashi M, Okamoto N, Sakamoto S, Iwasaki S, Asanuma T, Taniguchi T, Urade Y, Onishi S, Saibara T, Oben JA
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Journal Title
Liver Int
Volume: 31
Pages: 542-551
DOI
Peer Reviewed
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[Journal Article] Super paramagnetic iron Oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease2010
Author(s)
Asanuma T, Ono M, Kubota K, Hirose A, Hayashi Y, Saibara T, Inanami O, Ogawa Y, Enzan H, Onishi S, Kuwabara M Oben JA
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Journal Title
Gut
Volume: 59
Pages: 258-266
DOI
Peer Reviewed
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