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2011 Fiscal Year Final Research Report

Cancer therapy by vector co-expressing p53 and miRNA with RNA interference

Research Project

  • PDF
Project/Area Number 22790654
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionSapporo Medical University

Principal Investigator

IDOGAWA Masashi  札幌医科大学, 医学部, 助教 (00404749)

Project Period (FY) 2010 – 2011
Keywordsp53 / miRNA / MDM2 / p21 / アデノウイルスベクター / 癌 / アポトーシス
Research Abstract

We constructed adenovirus vector which express artificial miRNA targeting MDM2. Infection with this vector and vector which co-express p53 and artificial miRNA targeting p21 enhanced apoptosis more efficiently in cancer cells. This result suggests that adenovirus-mediated transduction of p53 and miRNAs targeting anti-apoptotic p53 target genes is useful for therapy of human cancers.

  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] CHFR regulates the mitotic checkpoint by targeting PARP-1 for ubiquitination and degradation2012

    • Author(s)
      Kashima L, Idogawa M, Mita H, Shitashige M, Yamada T, Ogi K, Suzuki H, Toyota M, Ariga H, Sasaki Y, Tokino T
    • Journal Title

      Journal of Biological Chemistry

      Volume: (in press)

    • DOI

      DOI:10.1074/jbc.M111.321828

    • Peer Reviewed
  • [Journal Article] p53 negatively regulates the hepatoma growth factor HDGF2011

    • Author(s)
      Sasaki Y, Negishi H, Idogawa M, Yokota I, Koyama R, Kusano M, Suzuki H, Fujita M, Maruyama R, Toyota M, Saito T, Tokino T
    • Journal Title

      Cancer Research

      Volume: 71(22) Pages: 7038-47

    • DOI

      DOI:10.1158/0008-5472.CAN-11-1053

    • Peer Reviewed
  • [Journal Article] Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene2010

    • Author(s)
      Yokota I, Sasaki Y, Kashima L, Idogawa M, Tokino T
    • Journal Title

      International Journal of Oncology

      Volume: 37(6) Pages: 1407-16

    • DOI

      DOI:10.3892/ijo_00000792

    • Peer Reviewed
  • [Presentation] ゲノム網羅的shRNAライブラリースクリーニングに基づく人工miRNA/p53共発現による癌治療2011

    • Author(s)
      井戸川雅史, 佐々木泰史, 鹿島理沙, 篠村恭久, 今井浩三, 時野隆至
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-03
  • [Presentation] Apoptosis induction in cancer cells by the simultaneous transduction of p53 and artificial miRNAs based on the screening of genome-wide shRNA library2011

    • Author(s)
      Idogawa M, Sasaki Y, Kashima L, Shinomura Y, Imai K, Tokino T
    • Organizer
      American Association of Cancer Research(AACR) annual meeting
    • Place of Presentation
      Orlando, FL
    • Year and Date
      2011-04-06
  • [Presentation] p53とアポトーシス阻害的標的に対するmiRNAの単一アデノウイルス発現による癌治療2010

    • Author(s)
      井戸川雅史, 佐々木泰史, 鹿島理沙, 篠村恭久, 今井浩三, 時野隆至
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
  • [Presentation] Single adenovirus-mediated simultaneous expression of p53 and the artificial microRNAs targeting anti-apoptotic p53 target genes2010

    • Author(s)
      Idogawa M, Sasaki Y, Kashima L, Shinomura Y, Imai K, Tokino T
    • Organizer
      American Association of Cancer Research(AACR) annual meeting
    • Place of Presentation
      Washington D. C.
    • Year and Date
      2010-04-18

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Published: 2013-07-31  

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