2011 Fiscal Year Final Research Report
Development of noninvasive diagnosis by using IGF and IGFBP-1 for predicting nonalcoholic steatohepatitis(NASH).
| Project/Area Number |
22790660
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
YONEDA Masato 横浜市立大学, 附属病院, 助教 (10423831)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 非アルコール性脂肪肝炎 / 非アルコール性脂肪性肝疾患 / NASH / NAFLD / IGF / IGFBP-1 / 血小板 / シタグリプチン |
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| Research Abstract |
Nonalcoholic steatohepatitis(NASH) is rising rapidly. In Japan, the estimated prevalence of NASH in general population is reported about 3%. Liver biopsy is recommended as the gold standard for the diagnosis and staging of fibrosis in patients with NASH. In this study, we investigated biopsy-proven nonalcoholic fatty liver disease(NAFLD) patients. We found that (1) IGF-1 and IGFBP-1 correlated negatively to hepatic steatosis grade, (2) a high percentage of the impaired fasting glucose group developed of NASH, (3) the measurement of the platelet count, scoring systems(FIB4) were clinically useful for predicting severe fibrosis(stage 3-4) in NASH patients, and (4) sitagliptin may be a novel treatment for NASH.
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[Journal Article] Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease2012
Author(s)
Yoneda M, Naka S, Nakano K, Wada K, Endo H, Mawatari H, Imajo K, Nomura R, Hokamura K, Ono M, Murata S, Tohnai I, Sumida Y, Shima T, Kuboniwa M, Umemura K, Kamisaki Y, Amano A, Okanoue T, Ooshima T, Nakajima A.
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Journal Title
BMC Gastroenterol
Pages: 12-16
DOI
Peer Reviewed
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[Journal Article] Japan Study Group of Nonalcoholic Fatty Liver Disease(JSG-NAFLD). Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population2012
Author(s)
Sumida Y, Yoneda M, Hyogo H, Itoh Y, Ono M, Fujii H, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Fujita K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T
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Journal Title
BMC Gastroenterol
Volume: 5
Pages: 12-2
DOI
Peer Reviewed
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[Journal Article] Novel findings for the development of drug therapy for various liver diseases : Liver microsomal triglyceride transfer protein activator may be a possible therapeutic agent in non-alcoholic steatohepatitis2011
Author(s)
Fujita K, Imajo K, Shinohara Y, Nozaki Y, Wada K, Yoneda M, Endo H, Takahashi H, Abe Y, Inamori M, Shimamura T, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
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Journal Title
J Pharmacol Sci
Volume: 115
Pages: 270-3
URL
Peer Reviewed
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[Journal Article] Japan Study Group of Nonalcoholic Fatty Liver Disease. Platelet count for predicting fibrosis in nonalcoholic fatty liver disease2011
Author(s)
Yoneda M, Fujii H, Sumida Y, Hyogo H, Itoh Y, Ono M, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Imajo K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T
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Journal Title
J Gastroentero
Volume: 46
Pages: 1300-6
DOI
Peer Reviewed
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[Book] 診断と治療2011
Author(s)
米田正人, 今城健人, 河島圭吾, 中島淳
Total Pages
1523-1529
Publisher
診断と治療社
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[Book] 診断と治療2011
Author(s)
中島淳, 今城健人, 藤田浩司, 米田正人
Total Pages
1531-1538
Publisher
診断と治療社
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[Book] 非アルコール性肝疾患(NAFLD)における脾体積の検討.アルコールと医学生物学2010
Author(s)
鈴木香峰理, 桐越博之, 米田正人, 馬渡弘典, 藤田浩司, 高橋宏和, 阿部泰伸, 稲森正彦, 島村健, 小林規俊, 窪田賢輔, 斉藤聡, 中島淳
Total Pages
126-129
Publisher
東洋書店
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