2011 Fiscal Year Final Research Report
Development of liver fibrosis therapy targeting hepatic stellate cells by microRNA
| Project/Area Number |
22790666
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kinki University (2011)
Osaka City University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 星細胞 / マイクロRNA / 肝臓 / コラーゲン |
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| Research Abstract |
Some microRNAs important for activation and collagen production of stellate cells were identified. Among them, we showed that miR-29b is one of regulators of type I collagen mRNA and protein expression. Moreover, miR-29b downregulated in mouse activated stellate cells in vitro. Overexpression of miR-29b in mouse stellate cells not only decreased type I collagen mRNA and protein expression, but also inhibited stellate cell activation. We suggested that targeted genes of miR-29b were not only collagen 1A1 but stellate cell activation-related genes.
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