2011 Fiscal Year Final Research Report
Analysis of intestinal NK cells in pathology of inflammatory bowel diseases and examination about translatability of NK cells
| Project/Area Number |
22790668
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 炎症性腸疾患 |
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| Research Abstract |
We showed that the NKp44+/NKp46+NK cell is balanced in human normal intestinal mucosa, and the balance is disturbed in the intestinal mucosa in Crohn's disease. Moreover, the interaction between intestinal NKp46+NK cells and CD14+LPMφs is an important participant in the pathogenesis of Crohn's disease. IL-23 and the TL1A were the key factor of their interaction. These findings suggest that IFN-γ-producing NKp46+mucosal NK cell subset is involved in the pathogenesis of Crohn's disease.
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Research Products
(8 results)
