The Association between CDX2 and tyrosine kinases in chemotherapy refractory colorectal cancer and its mechanism.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22790670
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: FUNAKOSHI Shinsuke 慶應義塾大学, 医学部, 助教 (20297352)
• Research Collaborator: LYNCH John P University of Pennsylvania, epartment of Medicine, Division of Gastroenterology, Associate Professor of Medicine ; AZUMA Toshifumi 東京歯科大学, 歯学部, 教授 (00222612)
• Project Period (FY): 2010 – 2012
• Keywords: CDX2強制発現大腸癌細胞株 / 細胞接着 / Rac1 / IGF / c-MET / sp細胞

Research Abstract

Using MIGR1- control and MIGR-Cdx2-infected Colo205 cells, the phosphorylation states of several receptor tyrosine kinases and the expression of cell adhesion marker were analyzed. Secondly, in Colo 205 cells, Cdx2 increased caveolin in mRNA and protein l

Research Products

• [Presentation] Rac1 Activation Promotes Invasive Phenotype of Side Population in Colon Cancer Cells by Destabilizing the E-cadherin-β-catenin Ligation (2013)
  • Author(s): Shinsuke Funakoshi et al
  • Organizer: The AACR Annual Meeting 2013
  • Place of Presentation: Washington DC
  • Year and Date: 2013-04-09
• [Presentation] Inhibition of activated Rac1 signaling induces recovery of E-cadherin function and abrogation of invasive phenotype of side population in colon cancer cells. (2013)
  • Author(s): Shinsuke Funakoshi et al
  • Organizer: The 6th International Gastrointestinal Consensus Symposium (IGICS)
  • Place of Presentation: Tokyo
  • Year and Date: 2013-01-26
• [Presentation] Rac1 Activation Promotes Invasive Phenotype of Side Population in Colon Cancer Cells by Destabilizing the E-cadherin-βcatenin Ligation. (2012)
  • Author(s): Shinsuke Funakoshi et al
  • Organizer: The 8th International Symposium on cancer research and therapy
  • Place of Presentation: Tokyo
  • Year and Date: 2012-11-09
• [Presentation] 大腸癌細胞株におけるside population cell の分離と活性型Rac1 の発現および運動能の解析 (2012)
  • Author(s): 船越信介 他
  • Organizer: 第21回日本癌病態治療研究会ワークショップ2「癌診療:基礎医学からの提言」
  • Place of Presentation: 前橋
  • Year and Date: 2012-07-06
• [Presentation] Intestine-specific transcription factor Cdx2 enhances E-cadherin functionin colon cancer cells through caveolin-1 mediated suppression of the c-Abl/CrkL/Rac1 signaling pathway (2011)
  • Author(s): Shinsuke Funakoshi et al
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03