Identification of a biomarker of the epithelial stem cell and analysis of the regenerative and carcinogenic mechanisms of digestive tract

2012 Fiscal Year Final Research Report

• Project/Area Number: 22790676
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Kansai Medical University
• Principal Investigator: FUKUI Toshiro 関西医科大学, 医学部, 講師 (60402905)
• Research Collaborator: KISHIMOTO Masanobu 関西医科大学, 医学部, 大学院生 ; TKAHASHI Yu 関西医科大学, 医学部, 大学院生 ; SUZUKI Ryo 関西医科大学, 医学部, 大学院生 ; OKAZAKI Kazuichi 関西医科大学, 医学部, 教授 (70145126) ; MATSUZAKI Koichi 関西医科大学, 医学部, 准教授 (70278638) ; UCHIDA Kazushige 関西医科大学, 医学部, 講師 (40411516)
• Project Period (FY): 2010 – 2012
• Keywords: 上部消化管学(食道、胃、十二指腸) / 消化管上皮幹細胞

Research Abstract

We have identified the significant expression of pSmad2/3L-Thr in specific epithelial cells of the murine stomach, small intestine, and colon. We have suggested these cells to be epithelial stem cells in the G0 phase of the cell cycle before active proliferation.

Research Products

• [Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis (2011)
  • Author(s): Fukui T, Kishimoto M, Nakajima A, Yamashina M, Nakayama S, Kusuda T, Sakaguchi Y, Yoshida K, Uchida K, Nishio A, Matsuzaki K, Okazaki K
  • Journal Title: J Gastroenterol Volume: 46(4) Pages: 456-68
  • DOI: DOI:10.1007/s00535-010-0364-8
  • Peer Reviewed
• [Presentation] pSmad2/3L-Thrの消化管幹細胞マーカーとしての検討とその応用 (2013)
  • Author(s): 高橋悠
  • Organizer: 第99回日本消化器病学会総会(シンポジウム14「消化器領域における幹細胞研究の進歩」)
  • Place of Presentation: 鹿児島市
  • Year and Date: 20130321-20130323
• [Presentation] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in oesophagus (2012)
  • Author(s): Yu Takahashi
  • Organizer: 20th United European Gastroenterology Week
  • Place of Presentation: Amsterdam(オランダ)
  • Year and Date: 20121020-20121024
• [Presentation] The Specific Linker Phosphorylation of Smad2/3 Indicates Epithelial Stem Cells in Esophagus (2012)
  • Author(s): Yu Takahashi
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego(アメリカ合衆国)
  • Year and Date: 20120519-20120522
• [Presentation] 消化管上皮におけるpSmad2/3L-Thr陽性細胞の検討 (2012)
  • Author(s): 高橋悠
  • Organizer: 第98回日本消化器病学会総会(シンポジウム2「消化管stemcellの新たな展開」)
  • Place of Presentation: 東京
  • Year and Date: 20120419-20120421