2012 Fiscal Year Final Research Report
Novel therapeutic approaches of intestinal stenosis focused on myofibroblasts
| Project/Area Number |
22790677
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Fukuoka University |
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Principal Investigator |
KURAHARA Lin (HAI Lin) 福岡大学, 医学部, 講師 (00341438)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 下部消化管学(小腸、大腸) / 組織線維化 |
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| Research Abstract |
TRPC4 and C6 channels may play non-trivial roles in myofibroblast transformation/differentiation, thereby promoting fibrogenesis in the colon. Our results also suggested that myfibroblast signaling pathways regulating interleukin production, which seem associated with the phosphorylation of Smad2, Erk1/2, and p38 MAPK as well as TRPC6-mediated Ca2+ influx. TRPC4 and TRPC6 could be a promising target in treating fibrotic and inflammatory bowel diseases.
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