• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Elucidation of physiological function and mechanism of DA-Raf in cardiac hypertrophy and heart failure

Research Project

  • PDF
Project/Area Number 22790688
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionChiba University

Principal Investigator

TAKANO Haruko  千葉大学, バイオメディカル研究センター, 機関研究員 (40532891)

Project Period (FY) 2010 – 2011
Keywords分子心臓病態学
Research Abstract

We have identified DA-Raf (deleted A-Raf), which is generated by alternative splicing from Araf gene. It contains the Ras-binding domain, but lacks the kinase domain. To elucidate physiological functions of DA-Raf and their mechanisms, we generated DAraf gene-deficient (KO) mice, in which Araf expression is not affected. Lung alveoli were poorly developed due to the lack of myofibroblasts in the KO mice. On the other hand, alveolar epithelial type 2 cells (AEC2), which expressed DA-Raf at high level, might transform by epithelial-mesenchymal transition to myofibroblasts. These results imply that DA-Raf plays essential roles in alveolarization by regulating the Ras-ERK pathway in AEC2-myofibrblast transition.

  • Research Products

    (9 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma2012

    • Author(s)
      Kinoshita T, Nohata N, Watanabe-Takano H, Yoshino H, Hidaka H, Fujimura L, Fuse M, Yamasaki T, Enokida H, Nakagawa M, Hanazawa T, Okamoto Y, Seki N.
    • Journal Title

      Int. J. Oncol

    • DOI

      DOI:10.3892/ijo.2012.1390.(2012)

    • Peer Reviewed
  • [Journal Article] Tumor suppressive microRNA-133a regulates novel targets : Moesin contributes to cancer cell proliferationand invasion in head and neck squamous cell carcinoma2012

    • Author(s)
      Kinoshita T, Nohata N, Fuse M, Hanazawa T, Kikkawa N, Fujimura L, Watanabe-Takano H, Yamada Y, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 418(2) Pages: 378-383

  • [Journal Article] CXCR4 expression on activated B cells is downregulated by CD63 and IL-212011

    • Author(s)
      Yoshida N, Kitayama D, Arima M, Sakamoto A, Inamine A, Watanabe-Takano H, Hatano M, Koike T, TokuhisaT.
    • Journal Title

      J. Immunol

      Volume: 186(5) Pages: 2800-2808

  • [Journal Article] Nebulin and N-WASP cooperate to cause IGF-I-induced sarcomeric actin filament formation2010

    • Author(s)
      Takano K, Watanabe-Takano H, Suetsugu S, Kurita S, Tsujita K, Kimura S, Karatsu T, Takenawa T, Endo T.
    • Journal Title

      Science

      Volume: 330(6010) Pages: 1536-1540

  • [Presentation] Ras-ERKカスケードのアンタゴニストDA-Rafは肺胞形成に不可欠である2011

    • Author(s)
      渡邊-高野晴子, 横山隆志, 幡野雅彦, 徳久剛史, 高野和儀, 遠藤剛
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
  • [Presentation] Ras-ERKカスケードの拮抗因子DA-Rafは肺胞形成に必須の役割を担っている2011

    • Author(s)
      渡邊-高野晴子, 横山隆志, 幡野雅彦, 徳久剛史, 高野和儀, 遠藤剛
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-28
  • [Presentation] Ras-ERKカスケードのアンタゴニストDA-Rafは肺形成を制御している2010

    • Author(s)
      渡邊-高野晴子, 横山隆志, 幡野雅彦, 徳久剛史, 高野和儀, 遠藤剛
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
  • [Presentation] 遺伝子ノックアウトマウスを用いたDA-Rafの生理的機能の解析2010

    • Author(s)
      渡邊-高野晴子, 幡野雅彦, 横山隆志, 藤村理紗, 徳久剛史, 高野和儀, 遠藤剛
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-21
  • [Book] 「NebulinとN-WASPの複合体がIGF-1による筋原線維のアクチン線維形成を担う」実験医学,29(8)(5月号)2011

    • Author(s)
      高野和儀, 渡邊-高野晴子, 遠藤剛
    • Total Pages
      1273-1276
    • Publisher
      羊土社

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi