2011 Fiscal Year Final Research Report
Elucidation of physiological function and mechanism of DA-Raf in cardiac hypertrophy and heart failure
| Project/Area Number |
22790688
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
TAKANO Haruko 千葉大学, バイオメディカル研究センター, 機関研究員 (40532891)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 分子心臓病態学 |
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| Research Abstract |
We have identified DA-Raf (deleted A-Raf), which is generated by alternative splicing from Araf gene. It contains the Ras-binding domain, but lacks the kinase domain. To elucidate physiological functions of DA-Raf and their mechanisms, we generated DAraf gene-deficient (KO) mice, in which Araf expression is not affected. Lung alveoli were poorly developed due to the lack of myofibroblasts in the KO mice. On the other hand, alveolar epithelial type 2 cells (AEC2), which expressed DA-Raf at high level, might transform by epithelial-mesenchymal transition to myofibroblasts. These results imply that DA-Raf plays essential roles in alveolarization by regulating the Ras-ERK pathway in AEC2-myofibrblast transition.
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Research Products
(9 results)
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[Journal Article] Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma2012
Author(s)
Kinoshita T, Nohata N, Watanabe-Takano H, Yoshino H, Hidaka H, Fujimura L, Fuse M, Yamasaki T, Enokida H, Nakagawa M, Hanazawa T, Okamoto Y, Seki N.
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Tumor suppressive microRNA-133a regulates novel targets : Moesin contributes to cancer cell proliferationand invasion in head and neck squamous cell carcinoma2012
Author(s)
Kinoshita T, Nohata N, Fuse M, Hanazawa T, Kikkawa N, Fujimura L, Watanabe-Takano H, Yamada Y, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 418(2)
Pages: 378-383
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