2011 Fiscal Year Final Research Report
Role of chronic inflammation in cardiac lipotoxicity
| Project/Area Number |
22790691
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
EGUCHI Kosei 東京大学, 医学部・附属病院, 助教 (20529094)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 慢性炎症 |
|---|
| Research Abstract |
We first developed a novel method to specifically increase the serum palmitate level in mice. In this model, strong induction of inflammation in the pancreatic islet, blood vessel smooth muscle cells and the heart was observed that was found to be one of the causes of the dysfunction in these organs. Our results suggest that free fatty acids are one of the factors that induce chronic inflammation and dysfunction in the cardiovascular and metabolic systems in obesity.
|
-
[Journal Article] Saturated fatty acid and TLR signaling linkβcell dysfunction and islet inflammation2012
Author(s)
Kosei Eguchi, Ichiro Manabe, Yumiko Oishi-Tanaka, Mitsuru Ohsugi, Nozomu Kono, Fusa Ogata, Nobuhiro Yagi, Umeharu Ohto, Masao Kimoto, Kensuke Miyake, Kazuyuki Tobe, Hiroyuki Arai, Takashi Kadowaki, Ryozo Nagai
-
Journal Title
Cell Metabolism
Volume: 15
Pages: 518-533
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
