2011 Fiscal Year Final Research Report
Role of angiotensin II type 1 receptor in macrophage polarization and function
| Project/Area Number |
22790707
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
SUZUKI Jun 愛媛大学, 大学院・医学系研究科, 講師 (40452693)
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| Project Period (FY) |
2010 – 2011
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| Keywords | マクロファージ / 動脈硬化 / プラーク破綻 / アンジオテンシンII / 受容体 |
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| Research Abstract |
Stimulation of the angiotensin II type 1 receptor induces macrophage polarization to inflammatory M1 state and activates macrophage phagocytic function. Angiotensin II type 1 receptor also plays an important role in oxidized LDL-induced macrophage trapping in the atherosclerotic lesions via enhancing CD36 expression and focal adhesion kinase activation. Our results suggest that stimulation of the angiotensin II type 1 receptor modulates macrophage polarity and functions, resulting in atherosclerotic plaque instability.
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