2011 Fiscal Year Final Research Report
Explication of organ specific pathogenesis in patients with cardiac Fabry disease using induced pluripotent stem cells
| Project/Area Number |
22790716
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | iPS細胞 / 心Fabry病 |
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| Research Abstract |
The purpose of this study is to explicate organ specific pathogenesis in patients with cardiac Fabry disease using induced pluripotent stem cells. Upon approval of our local ethical committee, cardiac Fabry patient derived fibroblasts were established. Despite the success of establishment of iPS cells from healthy donor, we are not able to establish iPS cells from cardiac Fabry patient derived fibroblasts using lentiviral or retroviral reprogramming gene transduction. Further study is definitely required to reveal the role of defective enzyme alpha-galactosidase A in the process of reprogramming into iPS cells
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