The Impact of Intensive Glycemic Control on Stablization of Coronary Vulnerable Plaque in Patients with Diabetes Mellitus

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790736
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Hyogo Medical University
• Principal Investigator: FUJII Kenichi 兵庫医科大学, 医学部, 講師 (90434943)
• Project Period (FY): 2010 – 2011
• Keywords: 冠動脈不安定粥腫 / 糖尿病 / 動脈硬化

Research Abstract

OCT was performed in all 3 major coronary arteries of 70 patients with acute myocardial infarction to evaluate the impact of diabetes mellitus on the incidence of coronary vulnerable plaque. The incidences of TCFA at culprit lesions were similar. However, non-culprit-lesion TCFAs were observed more frequently in diabetic patients than in non-diabetic patients.
Then, diabetic patients were randomly allocated to intensive glycemic control, targeting a glycosylated hemoglobin(HbA1c) level<6.5%, or standard glycemic control, targeting an HbA1c level of> 7.0%. However, there were no significant differences observed in percent changes in the fibrous cap thickness, lipid arc, and volume of lipidic component between patients with intensive glycemic control and patients with standard treatment.

Research Products

• [Journal Article] Multiple Complex Coronary Atherosclerosis in Diabetic Patients with Acute Myocardial Infarction : A Three-Vessel Optical Coherence Tomography Study (2012)
  • Author(s): Fukunaga M, Fujii K, Kawasaki D, Akahori H, Nakata T, Shibuya M, Kawai K, Masutani M, Lee-Kawabata M, Tsujino T, Ohyanagi M, Masuyama T.
  • Journal Title: Eurointervention Volume: (in press)
  • Peer Reviewed
• [Journal Article] The impact of pravastatin pre-treatment on periprocedural microcirculatory damage in patients undergoing percutaneous coronary intervention (2011)
  • Author(s): Fujii K, Kawasaki D, Oka K, Akahori H, Iwasaku T, Fukunaga M, Eguchi A, Sawada H, Masutani M, Lee-Kawabata M, Tsujino T, Ohyanagi M, Masuyama T.
  • Journal Title: JACC Cardiovasc Interv Volume: 4(5) Pages: 513-20
  • Peer Reviewed
• [Journal Article] Preprocedural Evaluation and Endovascular Treatment of Iliofemoral Artery Disease Without Contrast Media for Patients With Pre-Existing Renal Insufficiency (2011)
  • Author(s): Kawasaki D, Fujii K, Fukunaga M, Fujii N, Masutani M, Kawabata ML, Tsujino T, Ohyanagi M, Masuyama T.
  • Journal Title: Circ J. Volume: 75(1) Pages: 179-84
  • Peer Reviewed
• [Journal Article] Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation (2011)
  • Author(s): Fujii K, Kawasaki D, Oka K, Akahori H, Fukunaga M, Sawada H, Masutani M, Lee-Kawabata M, Tsujino T, Ohyanagi M, Masuyama T.
  • Journal Title: Heart Volume: 97(12) Pages: 977-82
  • Peer Reviewed
• [Journal Article] OCT assessment of thin-cap fibroatheroma distribution in native coronary arteries (2010)
  • Author(s): Fujii K, Kawasaki D, Masutani M, Okumura T, Akagami T, Sakoda T, Tsujino T, Ohyanagi M, Masuyama T.
  • Journal Title: JACC Cardiovasc Imaging Volume: 3(2) Pages: 168-75
  • Peer Reviewed
• [Presentation] Optimal Endpoints for Stent Implantation and Guidance : A Review of the IVUS Literature (2012)
  • Author(s): Fujii K, et al.
  • Organizer: American College of Cardiology Scientific Session 2012
  • Place of Presentation: Chicago, USA
  • Year and Date: 2012-03-26
• [Presentation] Practical Pitfalls of OCT in Plaque Characterization : SA vs. ACS (2012)
  • Author(s): Fujii K.
  • Organizer: 5th Imaging & Physiology Summit 2012
  • Place of Presentation: Korea, Seoul
  • Year and Date: 2012-01-07
• [Presentation] Histopathological Validation of Optical Coherence Tomography Analysis for Lipid-Rich Plaque and Thin-Cap Fibroatheroma (2011)
  • Author(s): Fujii K, et al.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-11-15
• [Presentation] Multiple Complex Coronary Atherosclerosis In Diabetic Patients With Acute Myocardial Infarction : A Three-Vessel Optical Coherence Tomography Study (2011)
  • Author(s): Fukunaga M, Fujii K, et al.
  • Organizer: European Society of Cardiology 2011 Scientific Session
  • Place of Presentation: Paris, France
  • Year and Date: 2011-08-29
• [Presentation] Diagnostic Value of Index of Microcirculatory Resistance for Detection of Microcirculatory Damage Early After Anterior versus Non-anterior Myocardial Infarction (2011)
  • Author(s): Fukunaga M, Fujii K, et al.
  • Organizer: American College of Cardiology Scientific Session 2011
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2011-04-03
• [Presentation] Association of endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents three months after implantation (2010)
  • Author(s): Fujii K, et al.
  • Organizer: American Heart Association Scientific Sessions 2010
  • Place of Presentation: Chicago, USA
  • Year and Date: 20101113-17
• [Presentation] Effect of atorvastatin on the stability of thin-cap fibroatheroma : a three-vessel optical coherence tomography and intravascular ultrasound study (2010)
  • Author(s): Fujii K, et al.
  • Organizer: (Featured Research Session) Japan Circulation Society Scientific Session 2010
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-05