2011 Fiscal Year Final Research Report
Association between cerebrovascular disease and store-operated calcium channe
| Project/Area Number |
22790740
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Fukuoka Dental College |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 脳血管障害 / 動脈硬化 / カルシウムイオン |
|---|
| Research Abstract |
A rise in cytoplasmic Ca2+concentration is a key messenger of cell signaling. STIM1 is a sensor of cytoplasmic Ca2+concentration and regulates store-operated calcium entry(SOCE). A strong immunoreactivity of STIM1 was detected aroud aortic plaques in mice. We hypothesize that STIM1 determines whether monocyte differentiates into pro-inflammatory M1 macrophage or anti-inflammatory M2 macrophage. We are verifying it in established monocyte cell lines and human primary monocytes.
|
