2011 Fiscal Year Final Research Report
The role of lysophosphatidic acid in acute lung injury
| Project/Area Number |
22790745
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 急性肺損傷 / 活性化脂質 / 炎症 / 組織修復 / 細菌性肺炎 |
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| Research Abstract |
To elucidate the contribution of ATX and LPA to acid-induced lung injury, we examined the changes in the enzymatic activity of ATX in blood and BALF. We also examined the effect of anti-ATX blocking antibodies on the progression of acid-induced lung injury. We observed that acid instillation increased the enzymatic activity of ATX in BALF. Decreasing ATX activity attenuated the increased pulmonary permeability induced by acid-instillation. These data suggest that ATX and its product LPA are involved in pulmonary edema in acid-induced acute lung injury.
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Research Products
(2 results)
