2012 Fiscal Year Final Research Report
Effectiveness of 18^F-FLT and 18^F-FDG PET Imaging in Patients with Non-small Cell Lung Cancer
| Project/Area Number |
22790752
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
UMEDA Yukihiro 福井大学, 医学部附属病院, 助教 (80401975)
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| Research Collaborator |
OKAZAWA Hidehiko 福井大学, 高エネルギー医学研究センター, 教授
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| Project Period (FY) |
2010 – 2012
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| Keywords | 臨床呼吸器学 / 非小細胞肺癌 / ^18F-fluoro-thymidine |
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| Research Abstract |
To clarify the effectiveness of ^18 F-FLT and ^18 F-FDG PET imaging in patients with non-small cell lung cancer (NSCLC), we evaluated ^18 F-FLT and ^18 F-FDG uptake of pulmonary lesion before and after systemic chemotherapy. Change in FDG uptake after 1 course of systemic chemotherapy predicted therapeutic response better than that in FLT uptake. On the other hand, the baseline FDG and FLT uptake predicted overall survival of patients with advanced NSCLC (cut-off of FDG SUVmax 11.0, P=0.014; cut-off of FLT SUVmax 5.0, P=0.012, log rank test). Furthermore, the value multiplied FDG and FLT uptake (cut-off 80, P=0.002, log rank test).
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