The role of surfactant protein A in lung cancer progression and metastasis.

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790759
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: GOTO Hisatsugu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (00437641)
• Research Collaborator: MITSUHASHI Atsushi 徳島大学, 大学院・学生医科学教育部, 医学専攻2年生
• Project Period (FY): 2010 – 2011
• Keywords: 肺がん / サーファクタント

Research Abstract

Human SP-A gene was introduced into the human lung adenocarcinoma cell line, and in vivo effect of SP-A over-expression on cancer progression was examined in experimental mouse model. Lung tumor produced by SP-A over-expression cells had ; 1. less tumor burden and pleural effusion, 2. increased number of infiltrated macrophages, 3. increased number of M1 macrophages(anti-tumor macrophages). SP-A may have a protective role in lung cancer progression through modulating host immune response.

Research Products

• [Journal Article] Erlotinib prevents experimental metastases of human small cell lung cancer cells with no epidermal growth factor receptor expression (2012)
  • Author(s): Gabr AG, Goto H, Hanibuchi M, Ogawa H, Kuramoto T, Suzuki M, Saijo A, Kakiuchi S, Trung VT, Sakaguchi S, Moriya Y, Sone S, and Nishioka Y.
  • Journal Title: Clin Exp Metastasis Volume: 29(3) Pages: 207-216
  • Peer Reviewed
• [Journal Article] Investigation of the outpatient chemotherapy for lung cancer patients in Tokushima University Hospital (2011)
  • Author(s): Goto H, Hanibuchi M, Sakaguchi S, Kanematsu T, Kakiuchi S, Tomimoto H, Azuma M, Tezuka T, Tada H, Miki Y, Nakamura T, Sone S, and Nishioka Y.
  • Journal Title: J Med Invest Volume: 58(3-4) Pages: 219-226
  • Peer Reviewed
• [Journal Article] E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor (2011)
  • Author(s): Ogino H, Hanibuchi M, Kakiuchi S, Trung VT, Goto H, Ikuta K, Yamada T, Uehara H, Tsuruoka A, Uenaka T, Wang W, Li Q, Takeuchi S, Yano S, Nishioka Y, and Sone S.
  • Journal Title: Mol Cancer Ther Volume: 10(7) Pages: 1218-1228
  • Peer Reviewed
• [Presentation] Surfactant protein A suppresses progression of human lung adenocarcinoma in nude mice via modulating host immune response (2012)
  • Author(s): 三橋惇志
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター(神戸市)
  • Year and Date: 2012-04-21
• [Presentation] Surfactant protein A suppresses progression of human lung adenocarcinoma in an experimental lung metastasis model (2011)
  • Author(s): 三橋惇志
  • Organizer: American Thoracic Society International Conference 2011
  • Place of Presentation: コロラドコンベンションセンター(アメリカ合衆国デンバー)
  • Year and Date: 2011-05-17
• [Book] 呼吸 (2012)
  • Author(s): 後東久嗣
  • Total Pages: 100
  • Publisher: レスピレーションリサーチファンデーション