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2011 Fiscal Year Final Research Report

The role of surfactant protein A in lung cancer progression and metastasis.

Research Project

  • PDF
Project/Area Number 22790759
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

GOTO Hisatsugu  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (00437641)

Research Collaborator MITSUHASHI Atsushi  徳島大学, 大学院・学生医科学教育部, 医学専攻2年生
Project Period (FY) 2010 – 2011
Keywords肺がん / サーファクタント
Research Abstract

Human SP-A gene was introduced into the human lung adenocarcinoma cell line, and in vivo effect of SP-A over-expression on cancer progression was examined in experimental mouse model. Lung tumor produced by SP-A over-expression cells had ; 1. less tumor burden and pleural effusion, 2. increased number of infiltrated macrophages, 3. increased number of M1 macrophages(anti-tumor macrophages). SP-A may have a protective role in lung cancer progression through modulating host immune response.

  • Research Products

    (6 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Erlotinib prevents experimental metastases of human small cell lung cancer cells with no epidermal growth factor receptor expression2012

    • Author(s)
      Gabr AG, Goto H, Hanibuchi M, Ogawa H, Kuramoto T, Suzuki M, Saijo A, Kakiuchi S, Trung VT, Sakaguchi S, Moriya Y, Sone S, and Nishioka Y.
    • Journal Title

      Clin Exp Metastasis

      Volume: 29(3) Pages: 207-216

    • Peer Reviewed
  • [Journal Article] Investigation of the outpatient chemotherapy for lung cancer patients in Tokushima University Hospital2011

    • Author(s)
      Goto H, Hanibuchi M, Sakaguchi S, Kanematsu T, Kakiuchi S, Tomimoto H, Azuma M, Tezuka T, Tada H, Miki Y, Nakamura T, Sone S, and Nishioka Y.
    • Journal Title

      J Med Invest

      Volume: 58(3-4) Pages: 219-226

    • Peer Reviewed
  • [Journal Article] E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor2011

    • Author(s)
      Ogino H, Hanibuchi M, Kakiuchi S, Trung VT, Goto H, Ikuta K, Yamada T, Uehara H, Tsuruoka A, Uenaka T, Wang W, Li Q, Takeuchi S, Yano S, Nishioka Y, and Sone S.
    • Journal Title

      Mol Cancer Ther

      Volume: 10(7) Pages: 1218-1228

    • Peer Reviewed
  • [Presentation] Surfactant protein A suppresses progression of human lung adenocarcinoma in nude mice via modulating host immune response2012

    • Author(s)
      三橋惇志
    • Organizer
      第52回日本呼吸器学会学術講演会
    • Place of Presentation
      神戸コンベンションセンター(神戸市)
    • Year and Date
      2012-04-21
  • [Presentation] Surfactant protein A suppresses progression of human lung adenocarcinoma in an experimental lung metastasis model2011

    • Author(s)
      三橋惇志
    • Organizer
      American Thoracic Society International Conference 2011
    • Place of Presentation
      コロラドコンベンションセンター(アメリカ合衆国デンバー)
    • Year and Date
      2011-05-17
  • [Book] 呼吸2012

    • Author(s)
      後東久嗣
    • Total Pages
      100
    • Publisher
      レスピレーションリサーチファンデーション

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Published: 2013-07-31  

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