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2011 Fiscal Year Final Research Report

Exploration of micro RNA regulating lung fibrosis and epithelial mesenchymal transition

Research Project

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Project/Area Number 22790763
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionUniversity of Miyazaki

Principal Investigator

YANAGI Shigehisa  宮崎大学, 医学部, 助教 (60404422)

Project Period (FY) 2010 – 2011
Keywords肺線維症 / マイクロRNA
Research Abstract

To determine the role of epithelial Pten in lung fibrosis, we compared the responses to bleomycin administration between wild-type and bronchioalveolar epithelium-specifically Pten-deleted[SP-C-rtTA/(tetO)_7-Cre/Pten^Δ/Δ(SOPten^Δ/Δ) mouse. Epithelial-derived myofibroblasts were increased in epithelium-specific Pten-deficient mice. Lungs of bleomycin-treated SOPten^Δ/Δmice showed increased pAkt, pS6K, Snai expressions. Akt inactivation definitively saved SOPtenΔ/Δmice. Finally, we detected a reduction of PTEN expression and AKT hyperactivation in the AECs of human IPF lungs. Our results highlight epithelial Pten as a crucial gatekeeper controlling lung fibrosis by modulating integrity of AECs.

  • Research Products

    (6 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation2011

    • Author(s)
      Imazu Y, Yanagi S, Miyoshi K, Tsubouchi H, Yamashita S, Matsumoto N, Ashitani J, Kangawa K, Nakazato M
    • Journal Title

      Eur J Pharmacol

      Volume: 15 Pages: 153-158

    • Peer Reviewed
  • [Presentation] Lung cancer, Lung tissue stem cell, and Lung cancer stem cell(Symposium)2011

    • Author(s)
      Yanagi S
    • Organizer
      The 9th Annual Meeting of Japanese Society of Medicine Oncology
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-07-22
  • [Presentation] Epithelial Pten plays an essential role in preventing pulmonary fibrosis by regulating the epithelial-mesenchymal transition2011

    • Author(s)
      Yanagi S, Miyoshi K, Tsubouchi H, Imazu Y, Matsumoto N, Nakazato M
    • Organizer
      106thAmerican Thoracic Society International Conference
    • Place of Presentation
      Denver, Colorado. USA
    • Year and Date
      2011-05-16
  • [Presentation] Epithelial Pten plays an essential role in preventing pulmonary fibrosis by regulating the epithelial-mesenchymal transition2011

    • Author(s)
      Miyoshi K, Yanagi S, Tsubouchi H, Imazu Y, Matsumoto N, Yamashita S, Nakazato M
    • Organizer
      The 51st Annual Meeting of The Japanese Respiratory Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-04-22
  • [Presentation] 特発性肺線維症の細気管支肺胞上皮におけるPten/PI3K/Akt経路関連分子発現に関する検討2010

    • Author(s)
      坪内拡伸, 柳重久, 三好かほり, 中里雅光
    • Organizer
      第50回日本呼吸器学会学術講演
    • Place of Presentation
      京都
    • Year and Date
      2010-04-25
  • [Book] 肺癌とHIFs. Annual Review呼吸器20122011

    • Author(s)
      柳重久、三好かほり、坪内拡伸、中里雅光
    • Total Pages
      46-56

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Published: 2013-07-31  

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