2011 Fiscal Year Final Research Report
Studies on host defense mechanisms of pulmonary collectins against Legionella pneumophila.
| Project/Area Number |
22790764
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
ARIKI Shigeru 札幌医科大学, 医学部, 助教 (80464478)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 肺コレクチン / 自然免疫 / 細胞内寄生細菌 |
|---|
| Research Abstract |
Pulmonary collectins play important roles in innate immunity of the lung. In this study, we found that pulmonary collectins attenuate autophagy induced by L. pneumophila infection. Furthermore, pulmonary collectins inhibit the secretion of effector molecules into host cells via type IV secretion system of L. pneumophila. These results suggest that pulmonary collectins protect host cells by the previously uncharacterized host defense mechanism against intracellular pathogen.
|
