2012 Fiscal Year Final Research Report
Role of MMPs in refractory asthma
| Project/Area Number |
22790766
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 閉塞性肺疾患 |
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| Research Abstract |
Because it is well known that airway remodeling contributes to the refractoriness of asthma and MMPs play an important role in the formation of remodeling, we explored the factors that affect the production and activation of matrix metalloproteinase (MMPs) by lung fibroblast, one of the main producer of MMPs in the lung. We found that peroxynitrite, one of the potent oxidants, and activation of toll like receptor (TLR)-3 are the contributors of excessive MMP production and activation by lung fibroblasts. These results suggest that reactive nitrogen species and the TLR3 pathway are related with MMP-mediated airway remodeling.
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[Journal Article] 25-hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway.2013
Author(s)
Ichikawa T, Sugiura H, Koarai A, Kikuchi T, Hiramatsu M, Kawabata H, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M.
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Journal Title
Exp Cell Res
Volume: 319
Pages: 1176-86
Peer Reviewed
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[Journal Article] 25-Hydroxycholesterol enhances cytokine release and Toll-like receptor 3 response in airway epithelial cells.2012
Author(s)
Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Kikuchi T, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M.
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Journal Title
Peer Reviewed
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[Journal Article] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics.2012
Author(s)
Matsunaga K, Yanagisawa S, Hirano T, Ichikawa T, Koarai A, Akamatsu K, Sugiura H, Minakata Y, Matsunaga K, Kawayama T, Ichinose M.
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Journal Title
Clin Exp Allergy
Volume: 42
Pages: 775-81
Peer Reviewed
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[Journal Article] Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease.2012
Author(s)
Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Yanagisawa S, Furusawa M, Uno Y, Yamasaki M, Satomi Y, Ichinose M.
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Journal Title
Respirology
Volume: 17
Pages: 533-40
Peer Reviewed
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[Journal Article] Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts.2012
Author(s)
Sugiura H, Kawabata H, Ichikawa T, Koarai A, Yanagisawa S, Kikuchi T, Minakata Y, Matsunaga K, Nakanishi M, Hirano T, Akamatsu K, Furukawa K, Ichinose M.
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Journal Title
Am J Physiol Lung Cell Mol Physiol
Volume: 302
Pages: L764-74
Peer Reviewed
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[Journal Article] Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis.2012
Author(s)
Kikuchi T, Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, Nakanishi M, Hirano T, Akamatsu K, Yanagisawa S, Furukawa K, Kawabata H, Ichinose M.
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Journal Title
Chest
Volume: 142
Pages: 329-37
Peer Reviewed
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[Journal Article] Increase of nitrosative stress in patients with eosinophilic pneumonia.2011
Author(s)
Furukawa K, Sugiura H, Matsunaga K, Ichikawa T, Koarai A, Hirano T, Yanagisawa S, Minakata Y, Akamatsu K, Kanda M, Nishigai M, Ichinose M.
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Journal Title
Peer Reviewed
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[Journal Article] High COPD prevalence in patients with liver disease.2010
Author(s)
Minakata Y, Ueda H, Akamatsu K, Kanda M, Yanagisawa S, Ichikawa T, Koarai A, Hirano T, Sugiura H, Matsunaga K, Ichinose M.
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Journal Title
Intern Med.
Volume: 49
Pages: 2687-91
Peer Reviewed
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