2011 Fiscal Year Final Research Report
The role of costimulatory molecules in alveolar macrophages from a murine model of asthma
| Project/Area Number |
22790768
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 肺胞マクロファージ / 喘息 / 補助シグナル分子 |
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| Research Abstract |
Little is known about the population of alveolar macrophages(AM) from asthmatics. In the present study, we suggested that AM from a murine model of asthma transit towards an alternatively activated macrophages(M2) as compared with AM from control mice. Moreover, we found that AM from a murine model of asthma, but not from control mice, express the costimulatory molecule B7-DC, and AM might inhibit antigen-specific CD4 T cell proliferation. These findings suggest that AM can suppress the pathogenesis of asthma, and may be a novel therapeutic target in asthma.
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[Journal Article] Wound-induced TGF-beta1and TGF-beta2enhance airway epithelial repair via HB-EGF and TGF-alpha
Author(s)
Ito J, Harada N, Nagashima O, Makino F, Usui Y, Yagita H, Okumura K, Dorscheid D. R., Atsuta R, Akiba H, and Takahashi K
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Journal Title
Biochem Biophys Res Commun
Volume: 412
Pages: 109-114
Peer Reviewed
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