Analysis of hyperglycemia- and RAGE-induced allergic inflammation

2012 Fiscal Year Final Research Report

• Project/Area Number: 22790769
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Teikyo University
• Principal Investigator: SUZUKAWA Maho 帝京大学, 医学部, 助手 (20453699)
• Project Period (FY): 2010 – 2012
• Keywords: アレルギー / 生活習慣病 / 糖尿病 / 気管支喘息 / RAGE

Research Abstract

Advanced glycation end products (AGEs) are substances produced in high-glucose disease conditions and induce apoptosis and inflammatory cytokine secretion from human basophils. Human basophils express receptor for AGEs (RAGE). S100/A12 is another ligand for RAGE. S100/A12 induces airway inflammation in mice as well as upregulates inflammatory cytokine levels in bronchoalveolar lavage fluid in allergic mice.

Research Products

• [Journal Article] ORMDL-3 is an allergen inducible lung epithelial ER protein regulating metalloproteases, chemokines, OAS, and ATF6 (2012)
  • Author(s): Miller M, Tam A, Cho JY, Doherty T, Pham A, Khorram N, Rosenthal P, Mueller J, Hoffman H, Suzukawa M, Niwa M, Broide D
  • Journal Title: Proc Natl Acad Sci USA Volume: 109(41) Pages: 16648-53
  • Peer Reviewed
• [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma (2012)
  • Author(s): Suzukawa M, Morita H, Nambu A, Arae K,Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua DJ, Suto H,Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide D,Matsumoto K, Nakae S
  • Journal Title: J Immunol Volume: 189(7) Pages: 3641-52
  • Peer Reviewed
• [Journal Article] 好塩基球脱顆粒反応が陽性であった豆腐、および大豆を原因とするアナフィラキシーの2例 (2012)
  • Author(s): 杉本 直也, 中瀬 裕子, 鈴川 真穂, 田下浩之, 新井 秀宜, 長瀬 洋之, 加藤 愛香, 山口 正雄, 大田 健
  • Journal Title: アレルギーの臨床 Volume: 32巻7号 Pages: 650-653
  • Peer Reviewed
• [Journal Article] Leptin enhances survival and induces migration, degranulation and cytokine synthesis of human basophils (2011)
  • Author(s): Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, Koketsu R, Nakae S, Yamaguchi M, Ohta K
  • Journal Title: J Immunol Volume: 186(9) Pages: 5254-5260
  • Peer Reviewed
• [Journal Article] The in vitroeffects of advanced glycation end products on basophil functions (2011)
  • Author(s): Han K*, Suzukawa M* (* equally first authors), Yamaguchi M, Sugimoto N, Nakase Y, Toda T, Nagase H, Ohta K
  • Journal Title: Int Arch Allergy Immunol Volume: 155 Pages: 64-70
  • Peer Reviewed
• [Journal Article] A Case of Anaphylactic Reaction Following Matsutake Mushroom Ingestion: Demonstration of Histamine Release Reaction of Basophil (2011)
  • Author(s): Toda T, Yamaguchi M, Nakase Y, Sugimoto N, Suzukawa M, Nagase H, Ohta K
  • Journal Title: Allergol Int Volume: 59(4) Pages: 417-419
• [Presentation] Ken Ohta The role of advanced glycation endproducts (AGEs) on basophil functions
  • Author(s): Maho Suzukawa, Masao Yamaguchi, Kaiyu Han, Takako Toda, Hiroyuki Nagase
  • Organizer: American Academy of Allergy Asthma & Immunology 2011 Annual meeting
  • Place of Presentation: Washington DC, USA
• [Book] レプチンと好塩基球機能, 臨床免疫・アレルギー科58巻1号 (2012)
  • Author(s): 鈴川 真穂,大田 健
  • Total Pages: 99-104
• [Book] 咳喘息, 成人病と生活習慣病40巻11号 (2010)
  • Author(s): 鈴川 真穂,大田 健
  • Total Pages: 1257-1260
• [Book] IL-33による好塩基球と好酸球の活性化, 臨床免疫・アレルギー科53巻1号 (2010)
  • Author(s): 鈴川 真穂,大田 健
  • Total Pages: 21-28