2011 Fiscal Year Final Research Report
Evaluation of biomarkers in drug-induced acute kidney injury model
| Project/Area Number |
22790780
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NEGISHI Kosuke 東京大学, 医学部附属病院, 特任臨床医 (40572219)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 急性腎障害 / 薬剤性腎障害 / バイオマーカー / 脂肪酸結合蛋白 |
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| Research Abstract |
I evaluated the utility of urine L-FABP for Acute kidney injury(AKI) biomarker in animal drug-induced renal injury models induced by radio-contrast(RC), gentamicin and vancomycin. In RC-induced AKI model, L-FABP was shed into the urine in a dose-dependent manner, and was demonstrated that hypoperfusion of peri-tubular capillary was one of the key factors to induce its renal expression and the elevation of its urinary shedding. Furthermore, it was confirmed that L-FABP was a useful biomarker that responded to RC sensitively. However, additional biomarker studies are needed for gentamicin and vancomycin-induced AKI. In future, it is expected that further biomarker studies would improve diagnostic accuracy of drug-induced renal injury.
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