2011 Fiscal Year Final Research Report
Basic study for treatment of Japanese type of Cystinuria by peptidomimetic drugs
| Project/Area Number |
22790789
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
NAGAMORI Shushi 大阪大学, 大学院・医学系研究科, 助教 (90467572)
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| Project Period (FY) |
2010 – 2011
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| Keywords | トランスポーター / シスチン尿症 / 遺伝病 / ペプチドミメティック薬 / 病態モデル |
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| Research Abstract |
Cystinuria is an inherited disorder of renal reabsorption of cystine and dibasic amino acids by dysfunction of the transporter. It results in nephrollthalasis of cystine and leads to kidney failure. 80% of Japanese patients have the same mutation P482L at the C terminal of the cystine transporter. In this study, we have revealed the mechanism for the dysfunction of the mutant transporter in vitro and in vivo. This opens the door for treatment of the disease in the future.
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[Journal Article] Prognostic Significance of L-type Amino Acid Transporter 1 Expression in Surgically Resected Pancreatic Cancer2012
Author(s)
Kaira K., Sunose Y., Arakawa K., Ogawa T., Sunaga N., Shimizu K., TominagaH., Oriuchi N., Itoh H., Nagamori. S., Kanai Y., Segawa A., Furuya M., Mori M., Oyama T., Takeyoshi I.
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Journal Title
Br J Cancer
Volume: (in press)
Peer Reviewed
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[Journal Article] Transport of 3-fluoro-L-α-methyl tyrosine by tumor-upregulated amino acid transporter LAT1 : a cause of the tumor uptake in PET2012
Author(s)
Wiriyasermkul, P. Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R. Tanaka H, Endou H, Endo K, Sakurai H and Kanai Y
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Journal Title
J Nucl Med
Volume: (in press)
Peer Reviewed
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[Journal Article] Pathogenic GLUT9 Mutations Causing Renal Hypouricemia Type 2(RHUC2)2011
Author(s)
Kawamura Y, Matsuo H, Chiba T, Nagamori S, Nakayama A, Inoue H, Utsumi Y, Oda T, Nishiyama J, Kanai Y, Shinomiya N
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Journal Title
Nucleosides Nucleotides Nucleic Acids
Volume: 30
Pages: 1105-11
Peer Reviewed
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[Journal Article] Inhibition of L-type Amino Acid Transporter 1 Has Antitumor Activity in Non-small Cell Lung Cancer2010
Author(s)
Imai H., Kaira K., Oriuchi N., Shimizu K., Tominaga H., Yanagitani N., Sunaga N., Ishizuka T., Nagamori S., Promchan K., Nakajima T., Yamamoto N., Mori M., Kanai Y.
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Journal Title
Anticancer Res
Volume: 30
Pages: 4819-28
Peer Reviewed
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[Journal Article] A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules2010
Author(s)
Shiraya K., Hirata T., Hatano R., Nagamori S., Wiriyasermkul P., Jutabha P., Matsubara M., Muto S., Tanaka H., Asano S., Anzai N., Endou H., Yamada A., Sakurai H., Kanai Y.
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Journal Title
J Biol Chem
Volume: 285
Pages: 22141-51
Peer Reviewed
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