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2011 Fiscal Year Final Research Report

The Role of Receptor for AGEs(RAGE) on Low Turnover Bone

Research Project

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Project/Area Number 22790790
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionKobe University

Principal Investigator

HAMADA Yasuhiro  神戸大学, 医学部附属病院, 特命講師 (30397830)

Project Period (FY) 2010 – 2011
Keywords糖尿病 / 骨病変 / 合併症
Research Abstract

We have reported that diabetes induced low turnover bone in streptozotocin-induced diabetic mouse. It has been reported that AGEs and the receptor for AGEs(RAGE) have been linked to the pathogenesis of diabetic microangiopathy. However, the relationship between RAGE and alteration in bone metabolism is unclear. Therefore, in order to determine the role of RAGE in bone metabolism, we investigated the effects of RAGE deletion on bone metabolism under physiological and diabetic conditions using RAGE knockout mice(RAGE-KO). Eight-week-old male RAGE-KO and wild-type littermates(WT) were intraperitoneally injected with either streptozotocin or vehicle. Mice were divided into four groups : 1) nondiabetic WT ; 2) nondiabetic RAGE-KO ; 3) diabetic WT ; and 4) diabetic RAGE-KO. After 12 weeks of streptozotocin or vehicle treatment, the physical properties of femora and the static and dynamic parameters of bone histomorphometry of tibiae were assessed. The deletion of RAGE affected neither body weights nor hemoglobin A1c levels. RAGE deletion resulted in increased bone mineral density due to decreased osteoclast function under physiological conditions that is no accumulation of AGEs. In contrast, lacking RAGE did not affect the alteration in bone metabolism under diabetic conditions, suggesting that AGEs-RAGE interaction may not be involved in the pathogenesis of diabetic osteopenia, which expresses low turnover bone, although RAGE plays an important role in bone metabolism.

  • Research Products

    (5 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Carvedilol ameliorates low-turnover bone disease in non-obese type 2 diabetes2011

    • Author(s)
      Goto S, Fujii H, Kono K, Nakai K, Hamada Y, Yamato H, Shinohara M, Kitazawa R, Kitazawa S, Nishi S, Fukagawa M.
    • Journal Title

      Am J Nephrol

      Volume: 34(3) Pages: 281-90

    • Peer Reviewed
  • [Journal Article] The effects of the receptor for advancedglycation end products(RAGE) on bone metabolism under physiological and diabetic conditions2010

    • Author(s)
      Hamada Y, Kitazawa S, Kitazawa R, Kono K, Goto S, Komaba H, Fujii H, Yamamoto Y, Yamamoto H, Usami M, Fukagawa M.
    • Journal Title

      Endocrine

      Volume: 38(3) Pages: 369-76

    • Peer Reviewed
  • [Presentation] 抗酸化ストレス作用が低回転骨病変に及ぼす効果の解明2011

    • Author(s)
      濱田康弘
    • Organizer
      第4回慢性腎臓病病態研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-30
  • [Presentation] 糖尿病と骨病変2011

    • Author(s)
      濱田康弘
    • Organizer
      兵庫県糖尿病協会栄養部会
    • Place of Presentation
      神戸
    • Year and Date
      2011-06-11
  • [Presentation] 糖化最終産物(RAGE)の骨代謝における役割の解明2010

    • Author(s)
      濱田康弘
    • Organizer
      第3回CKD病態研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-31

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Published: 2013-07-31  

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