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2011 Fiscal Year Final Research Report

Development of EPO-producing cell using immortalize system

Research Project

  • PDF
Project/Area Number 22790792
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionKagawa University

Principal Investigator

HITOMI Hirofumi  香川大学, 医学部, 助教 (70346641)

Project Period (FY) 2010 – 2011
Keywords移植・再生医療 / 遺伝子 / エリスロポエチン / 腎性貧血 / 不死化細胞
Research Abstract

We developed immortalized cells derived from several cell lines to establish immortalize erythropoietin-producing cells. Erythropoietin production was easily detected using the reporter line system. Erythropoietin-producing cells which expressed GFP were selected by cell sorter. In addition, we developed an erythropoietin-overexpress vector, and confirmed the long-term production of erythropoietin in vector-tranfected cells.

  • Research Products

    (47 results)

All 2012 2011 2010 Other

All Journal Article (30 results) (of which Peer Reviewed: 30 results) Presentation (15 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation2012

    • Author(s)
      Hitomi H(他13名、9番目)
    • Journal Title

      Circulation

      Volume: 125 Pages: 1402-13

    • Peer Reviewed
  • [Journal Article] Aldosterone Induces Vascular Insulin Resistance by Increasing Insulin-Like Growth Factor-1 Receptor and Hybrid Receptor2012

    • Author(s)
      Hitomi H(他9名、10番目)
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Pages: 257-63

    • Peer Reviewed
  • [Journal Article] Aldosterone Does Not Contribute to Renal p21 Expression During the Development of Angiotensin II-Induced Hypertension in Mice2012

    • Author(s)
      Hitomi H(他9名、4番目)
    • Journal Title

      Am J. Hypertens

      Volume: 25 Pages: 354-8

    • Peer Reviewed
  • [Journal Article] Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats2012

    • Author(s)
      Hitomi H(他17名、11番目)
    • Journal Title

      Am J. Hypertens

      Volume: 25 Pages: 604-11

    • Peer Reviewed
  • [Journal Article] Systemic candesartan reduces brain angiotensin II via downregulation of brain renin-angiotensin system2012

    • Author(s)
      Hitomi H(他9名、6番目)
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 161-4

    • Peer Reviewed
  • [Journal Article] Angiotensin II shifts insulin signaling into vascular remodeling from glucose metabolism in vascular smooth muscle cells2011

    • Author(s)
      Hitomi H(他10名、1番目)
    • Journal Title

      Am J Hypertens

      Volume: 24 Pages: 1149-55

    • Peer Reviewed
  • [Journal Article] Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via EGF receptor-mediated ERK and Akt activation pathway2011

    • Author(s)
      Hitomi H(他11名、2番目)
    • Journal Title

      J Hypertension

      Volume: 29 Pages: 696-705

    • Peer Reviewed
  • [Journal Article] Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor2011

    • Author(s)
      Hitomi H(他10名、2番目)
    • Journal Title

      Exp Cell Res

      Volume: 317 Pages: 2420-8

    • Peer Reviewed
  • [Journal Article] Relationship between urinary angiotensinogen and salt sensitivity of blood pressure in patients with IgA nephropathy2011

    • Author(s)
      Hitomi H(他13名、8番目)
    • Journal Title

      Hypertension

      Volume: 58 Pages: 205-11

    • Peer Reviewed
  • [Journal Article] Effect of Efonidipine on TGF-β1-Induced Cardiac Fibrosis Through Smad2-Dependent Pathway in Rat Cardiac Fibroblasts. J2011

    • Author(s)
      Hitomi H(他10名、2番目)
    • Journal Title

      Pharmacol. Sci

      Volume: 117 Pages: 98-105

    • Peer Reviewed
  • [Journal Article] Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats2011

    • Author(s)
      Hitomi H(他10名、3番目)
    • Journal Title

      J Hypertension

      Volume: 29 Pages: 290-8

    • Peer Reviewed
  • [Journal Article] Angiotensin II induces human astrocyte senecence via reactive oxygen species production2011

    • Author(s)
      Hitomi H(他9名、3番目)
    • Journal Title

      Hypertens Res

      Volume: 34 Pages: 479-83

    • Peer Reviewed
  • [Journal Article] Blockade of angiotensin II AT1 receptors protects the blood brain barrier and congnition in Dahl salt-sensitive hypertensive rats2011

    • Author(s)
      Hitomi H(他13名、5番目)
    • Journal Title

      Am J Hypertens

      Volume: 24 Pages: 362-8

    • Peer Reviewed
  • [Journal Article] Aldosterone/ Mineralocorticoid receptor stimulation induces cellular senescence in the kidney2011

    • Author(s)
      Hitomi H(他13名、3番目)
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 680-8

    • Peer Reviewed
  • [Journal Article] Urinary angiotensinogen reflects the activity of intrarenal renin-angiotensin system in patients with IgA nephropathy2011

    • Author(s)
      Hitomi H(他12名、9番目)
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26 Pages: 170-7

    • Peer Reviewed
  • [Journal Article] Blood glucose level and survival in streptozotocin-treated human chymase transgenic mice2011

    • Author(s)
      Hitomi H(他10名、10番目)
    • Journal Title

      Chinese J Physiol

      Volume: 54 Pages: 30-5

    • Peer Reviewed
  • [Journal Article] Pathophysiological roles of aldosterone and mineralocorticoid receptor in the kidney2011

    • Author(s)
      Hitomi H(他3名、2番目)
    • Journal Title

      J Pharmacol Sci

      Volume: 115 Pages: 1-7

    • Peer Reviewed
  • [Journal Article] Possible involvement of the(pro) renin receptor-dependent system in the development of insulin resistance2011

    • Author(s)
      Hitomi H(他4名、2番目)
    • Journal Title

      Front Biosci

      Volume: 3 Pages: 1478-85

    • Peer Reviewed
  • [Journal Article] Roles of central renin-angiotensin system and afferent renal nerve in the control of systemic hemodynamics in rats2011

    • Author(s)
      Hitomi H(他8名、6番目)
    • Journal Title

      Hypertens Res

      Volume: 34 Pages: 1228-32

    • Peer Reviewed
  • [Journal Article] Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of Angiotensin II-induced IRS-1 phosphorylation by JNK2011

    • Author(s)
      Hitomi H(他6名、1番目)
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 301 Pages: C1415-22

    • Peer Reviewed
  • [Journal Article] Short-term calorie restriction in early life attenuates the development of proteinuria but not glucose intolerance in type 2 diabetic OLETF rats2011

    • Author(s)
      Hitomi H(他7名、4番目)
    • Journal Title

      ISRN Endocrinology

      Volume: 2011 Pages: 768637

    • Peer Reviewed
  • [Journal Article] Involvement of mineralocorticoid receptor in high glucose. induced BMK1 activation and mesangial cell proliferation2010

    • Author(s)
      Hitomi H(他11名、3番目)
    • Journal Title

      J Hypertension

      Volume: 28 Pages: 536-42

    • Peer Reviewed
  • [Journal Article] Role of(pro) renin receptor in cardiovascular cells from the aspect of signaling2010

    • Author(s)
      Hitomi H(他2名、1番目)
    • Journal Title

      Front Biosci

      Volume: 2 Pages: 1246-9

    • Peer Reviewed
  • [Journal Article] Mechanical stretch potentiates angiotensin II-induced proliferation in spontaneously hypertensive rat vascular smooth muscle cells2010

    • Author(s)
      Hitomi H(他8名、2番目)
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 1250-7

    • Peer Reviewed
  • [Journal Article] Mineralocorticoid receptor blockade enhances the anti-proteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats2010

    • Author(s)
      Hitomi H(他13名、13番目)
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 332 Pages: 1072-80

    • Peer Reviewed
  • [Journal Article] Role of caveolin and heat shock protein 70 interaction in the antioxidative effects of an angiotensin II type 1 receptor blocker in spontaneously hypertensive rats2010

    • Author(s)
      Hitomi H(他1名、2番目)
    • Journal Title

      J Hypertension

      Volume: 28 Pages: 9-12

    • Peer Reviewed
  • [Journal Article] Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats : possible involvement of N-type calcium channel in podocyte2010

    • Author(s)
      Hitomi H(他13名、8番目)
    • Journal Title

      J Hypertension

      Volume: 28 Pages: 1034-43

    • Peer Reviewed
  • [Journal Article] A novel clinical biomarker for MPO-ANCA associated glomerulonephritis2010

    • Author(s)
      Hitomi H(他5名、2番目)
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 37 Pages: 877-8

    • Peer Reviewed
  • [Journal Article] New approaches to blockade of the Renin-Angiotensin-Aldosterone system : Mineralocorticoid receptor blockers exert antihypertensive and renoprotective effects independently of the renin-angiotensin system2010

    • Author(s)
      Hitomi H(他3名、4番目)
    • Journal Title

      J Pharmacol Sci

      Volume: 113 Pages: 310-4

    • Peer Reviewed
  • [Journal Article] Regression of superficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria : effect of angiotensin II blockade2010

    • Author(s)
      Hitomi H(他12名、6番目)
    • Journal Title

      J Hypertension

      Volume: 28 Pages: 2289-98

    • Peer Reviewed
  • [Presentation] アルドステロンによるIGF-1受容体とハイブリッド受容体を介したインスリン抵抗性と血管リモデリングに与える影響2011

    • Author(s)
      人見浩史, 他
    • Organizer
      第20回循環薬理学会
    • Place of Presentation
      北海道
    • Year and Date
      2011-11-11
  • [Presentation] アルドステロンによるIGF-1受容体とHybrid受容体を介したインスリン抵抗性の検討2011

    • Author(s)
      人見浩史, 他
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-06-17
  • [Presentation] プロレニンのepidermal growth factor receptorを介した細胞内情報伝達系の解明2011

    • Author(s)
      人見浩史, 他
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-06-17
  • [Presentation] 細胞内pHと酸化ストレスを介したアンジオテンシンIIによるポドサイト障害機序の解明2010

    • Author(s)
      人見浩史, 他
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-17
  • [Presentation] アルドステロンによるIGF-1受容体とハイブリッド受容体を介したインスリンによる動脈硬化に与える影響2010

    • Author(s)
      人見浩史, 他
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-17
  • [Presentation] Aldosterone induses insulin resistance via up-regulation of IGF-1 receptor and its hybrid receptor in vitro and in vivo2010

    • Author(s)
      人見浩史, 他
    • Organizer
      64th Annual High Blood Pressure Research Conference 2010
    • Place of Presentation
      米国
    • Year and Date
      2010-10-14
  • [Presentation] アンジオテンシンIIによる細胞内pH変化と酸化ストレスを介したポドサイト障害の解明2010

    • Author(s)
      人見浩史, 他
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      兵庫
    • Year and Date
      2010-06-16
  • [Presentation] プロレニンの血管平滑筋細胞における受容体を介した細胞内情報伝達系の解明2010

    • Author(s)
      人見浩史, 他
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      兵庫
    • Year and Date
      2010-06-16
  • [Presentation] Effects of prorenin of vascular smooth muscle cell proliferation and hypertrophy via EGF receptor-mediated ERK and AKT activation pathway2010

    • Author(s)
      人見浩史, 他
    • Organizer
      12th Asian Pacific Congress of Nephrology
    • Place of Presentation
      韓国
    • Year and Date
      2010-06-05
  • [Presentation] Effects of mechanical stretch on insulin-induced vascular smooth muscle cell proliferation via upregulation of insulin-like growth factor-1 receptor2010

    • Author(s)
      人見浩史, 他
    • Organizer
      12th Asian Pacific Congress of Nephrology
    • Place of Presentation
      韓国
    • Year and Date
      2010-06-05
  • [Presentation] Effects of mechanical stretch on angiotensin II-induced cell proliferation in spontaneously hypertensive rat vascular smooth muscle cells2010

    • Author(s)
      人見浩史, 他
    • Organizer
      12th Asian Pacific Congress of Nephrology
    • Place of Presentation
      韓国
    • Year and Date
      2010-06-05
  • [Presentation] High sodium augments angiotensin II-induced proliferation of rat vascular smooth muscle cell through ERK1/ 2-dependent pathway2010

    • Author(s)
      人見浩史, 他
    • Organizer
      ISN Nexus
    • Place of Presentation
      京都
    • Year and Date
      2010-04-15
  • [Presentation] Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via EGF receptor-mediated ERK and Akt activation pathway2010

    • Author(s)
      人見浩史, 他
    • Organizer
      ISN Nexus
    • Place of Presentation
      京都
    • Year and Date
      2010-04-15
  • [Presentation] Mechanical streatch augments insulin-induced vascular smooth muscle cell proliferation by upregulation of insulin-like growth factor-1 receptor2010

    • Author(s)
      人見浩史, 他
    • Organizer
      ISN Nexus
    • Place of Presentation
      京都
    • Year and Date
      2010-04-15
  • [Presentation] Mechanical stretch potentiates angiotensin II-induced proliferation in spontaneously hypertensive rat vascular smooth muscle cells2010

    • Author(s)
      人見浩史, 他
    • Organizer
      ISN Nexus
    • Place of Presentation
      京都
    • Year and Date
      2010-04-15
  • [Book] 腎疾患・透析最新の治療2011-20132011

    • Author(s)
      人見浩史, 他
    • Total Pages
      26-30
    • Publisher
      南江堂
  • [Remarks]

    • URL

      http://www.kms.ac.jp/~yakuri/

URL: 

Published: 2013-07-31  

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