2011 Fiscal Year Final Research Report
Amelioration of AngiotensinII-induced salt-sensitive hypertension by L-FABP in proximal tubules
| Project/Area Number |
22790803
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | L-FABP / 食塩感受性高血圧 / レニン・アンジオテンシン系 / 酸化ストレス |
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| Research Abstract |
Recent findings indicated that inappropriate activation of the intrarenal renin-angiotensin system(RAS) induces reactive oxygen species production, which may contribute to salt-sensitive hypertension. On the other hand, L-FABP is expressed in renal proximal tubules in humans and may play an endogenous antioxidant role. The present study is to examine the antioxidative effect of L-FABP on salt-sensitive hypertension. The present findings indicated that L-FABP in proximal tubules may protect against AngII-induced SSHT in combination with attenuation of intrarenal RAS activation, oxidative stress. Therefore, L-FABP of proximal tubules may play a pathological role in SSHT.
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