2012 Fiscal Year Final Research Report
Novel neuroprotectant lithium in thrombolytic therapy
| Project/Area Number |
22790813
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳塞栓モデル / リチウム |
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| Research Abstract |
To investigate the neuroprotective effect of lithium with tissue plasminogen activator(t-PA) in thrombolytic therapy in stroke, I tried to establish the clinically-resembling animal stroke model. After several experimental condition had been tried, I've established the model that showed thrombolysis and neurological improvement by t-PA administration in early time point, and also showed worsened outcome including increased hemorrhage by t-PA administration in late time point. Similar animal model is not used in many reports because of the technical difficulty. Administration of lithium chloride after focal brain ischemia suppressed neurodegeneration through apoptosis. This protective effect was not related the activation of Akt.
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