2011 Fiscal Year Final Research Report
analysis of the pathomechanism of amyotrophic lateral sclerosis-focusing on Cajal bodies
| Project/Area Number |
22790814
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
YOKOSEKI Akio 新潟大学, 医歯学系, 特任准教授 (90515719)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ALS / TDP-43 / Cajal小体 / coilin |
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| Research Abstract |
TAR DNA binding protein of 43 kDa(TDP-43) is a major protein of ubiquitinated cytoplasmic inclusions in glia and neurons in amyotrophic lateral sclerosis(ALS). TDP-43 has been reported to associate with nuclear bodies : Cajal bodies, GEM bodies, PML, and SC35. Therefore, we focused on Cajal bodies. The mean number of Cajal bodies in sporadic ALS cases was statistically decreased than that in controls. Cajal bodies play an important function as maturation of small nuclear and nucleolar ribonucleoproteins. Taken together, neuronal death may be caused by dysregulation of transcription in ALS motor neurons.
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[Journal Article] Onodera O, Genotype-phenotype correlations in early onset ataxia with ocular motor apraxia and hypoalbuminemia2011
Author(s)
Yokoseki A, Ishihara T, Koyama A, Shiga A, Yamada M, Suzuki C, Sekijima Y, Maruta K, Tsuchiya M, Date H, Sato T, Tada M, Ikeuchi T, Tsuji S, Nishizawa M
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Journal Title
Brain
Volume: 134
Pages: 1387-1399
Peer Reviewed
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[Journal Article] Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-beta1 via clevage of proTGF-beta12011
Author(s)
Shiga A, Nozaki H, Yokoseki A, Nihonmatsu M, Kawata H, Kato T, Koyama A, Arima K, Ikeda M, Katada S, Toyoshima Y, Takahashi H, Tanaka A, Nakano I, Ikeuchi T, Nishizawa M, Onodera O
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Journal Title
Hum Mol Genet
Volume: 20
Pages: 1800-1810
Peer Reviewed
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