The pathophysiological role of descending analgesia system in diabetic painful neuropathy

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790818
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: SANADA Mitsuru 滋賀医科大学, 医学部, 客員講師 (10418759)
• Project Period (FY): 2010 – 2011
• Keywords: 糖尿病性神経障害 / 疼痛 / 内向き整流性K+チャネル / 中脳水道周囲灰白質

Research Abstract

To clarify the pathophysiological role of descending analgesia system in diabetic painful neuropathy, we performed whole-cell patch clamp recordings from rat periaqueductal grey(PAG) neurons. Although the presence of the G protein-coupled, inwardly rectifying potassium current was detected in rat PAG neurons, there was no significant difference in current density between control and diabetic rats. This might be caused by the unstableness of the rat midbrain slice samples, and we need a further arrangement for the improvement of the electrophysiological recording system.

Research Products

• [Journal Article] Inactivation of TNF-αameliorates diabetic neuropathy in mice (2011)
  • Author(s): Yamakawa I, Kojima H, Terashima T, Katagi M, Oi J, Urabe H, Sanada M, Kawai H, Chan L, Yasuda H, Maegawa H, Kimura H.
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 301 Pages: E844-52
  • Peer Reviewed
• [Journal Article] Epidemiology of diabetic neuropathy (2010)
  • Author(s): Sanada M, Yasuda H.
  • Journal Title: Nihon Rinsho Volume: 68 Suppl 9 Pages: 538-41
• [Journal Article] Presence and functional role of the rapidly activating delayed rectifier K(+) current in left and right atria of adult mice (2010)
  • Author(s): Nakamura H, Ding WG, Sanada M, Maeda K, Kawai H, Maegawa H, Matsuura H.
  • Journal Title: Eur J Pharmacol Volume: 649 Pages: 14-22
  • Peer Reviewed
• [Presentation] 糖尿病性末梢神経障害におけるTNFαの関与と治療標的としての有用性 (2010)
  • Author(s): 山川勇、小島秀人、寺島智也、大井二郎、浦部博志、真田充、川合寛道、木村博、安田斎、前川聡
  • Organizer: 第25回糖尿病合併症学会
  • Place of Presentation: 大津
  • Year and Date: 2010-10-23
• [Presentation] 糖尿病性末梢神経障害におけるTNFαの関与と治療標的としての有用性 (2010)
  • Author(s): 山川勇、小島秀人、寺島智也、大井二郎、浦部博志、真田充、川合寛道、木村博、安田斎
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-21
• [Presentation] 高齢者糖尿病症例における膀胱機能障害:糖尿病性神経障害との関連から (2010)
  • Author(s): 真田充、片山由理、寺島智也、川合寛道、安田斎
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-21
• [Presentation] Lawrence Chan DRG-targeted helper-dependent adenovirus vectorによる感覚神経選択的遺伝子治療 (2010)
  • Author(s): 寺島智也、Kazuhiro Oka、Angelika Kritz、小島秀人、山川勇、川合寛道、真田充、片山由理、Andrew Baker
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-21