2011 Fiscal Year Final Research Report
The molecular mechanism in the development of pathogenic T-cell through HTLV-1 in HTLV-1-associated myelopathy(HAM)
| Project/Area Number |
22790833
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
ARAYA Natsumi 聖マリアンナ医科大学, 医学(系)研究科(研究院), 助教 (80440353)
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| Project Period (FY) |
2010 – 2011
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| Keywords | HTLV-1 / HAM / Tax / IFN-γ |
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| Research Abstract |
In HTLV-1 associated myelopathy(HAM), the pathogenesis is known as HTLV-1 infected CD4^+T-cells triggered hyper immune response, which leads to chronic inflammation of the central nervous system. In this study, it was demonstrated that HTLV-1 Tax induced the inflammatory cytokine IFN-γproduction through the transcriptional activation of T-bet in HTLV-1 infected CD4^+CD25^+CCR^4+T-cells. These results suggested that HTLV-1 infection-induced IFN-g producing cells resulting in plasticity of infected cells may play an important role in the development and pathogenesis of HAM.
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[Journal Article] Overexpression of SPACIA1/SAAL1, a new gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans2011
Author(s)
Sato T., Fujii R., Konomi K., Yagishita N., Aratani S., Araya N., Aono H., Yudoh K., Suzuki N., Beppu M., Yamano Y., Nishioka K., Nakajima T
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Journal Title
Arthritis Rheum
Volume: 63(12)
Pages: 3833-3842
DOI
Peer Reviewed
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[Journal Article] Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type1-associated neurological disease2011
Author(s)
Araya N., Takahashi K., Sato T., Nakamura T., Sawa C., Hasegawa D., Ando H., Aratani S., Yagishita N., Fujii R., Oka H., Nishioka K., Nakajima T., Mori N., Yamano Y
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Journal Title
Antivir Ther
Volume: 16(1)
Pages: 89-98
Peer Reviewed
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[Journal Article] Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes2011
Author(s)
Sato T., Konomi K., Fujii R., Aono H., Aratani S., Yagishita N., Araya N., Yudoh K., Beppu M., Yamano Y., Nishioka K., Nakajima T
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Journal Title
Ann Rheum Dis
Volume: 70(1)
Pages: 221-226
DOI
Peer Reviewed
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[Journal Article] E3 Ubiquitin Ligase Synoviolin Is Involved in Liver Fibrogenesis2010
Author(s)
Hasegawa D., Fujii R., Yagishita N., Matsumoto N., Aratani S., Izumi T., Azakami K., Nakazawa M., Fujita H., Sato T., Araya N., Koike J., Tadokoro M., Suzuki N., Nagata K., Senoo H., Friedman S. L., Nishioka K., Yamano Y., Itoh F., Nakajima T
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Journal Title
PLoS One
Volume: 5(10)
Pages: e13590
DOI
Peer Reviewed
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[Presentation] The plasticity of HTLV-1 infected CD4+CD25+CCR4+T-cells through HTLV-1 tax in HAM/TSP2011
Author(s)
Araya N., Sato T., Utsunomiya A., Ando H., Yagishita N., Kannagi M., Nakamura T., Tanaka Y., Jacobson S., Yamano Y
Organizer
15th International Conference on Human Retrovirology : HTLV and Related Viruses
Place of Presentation
Lauderdale, U. S. A
Year and Date
2011-06-05
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[Presentation] Clinical subtype of HAM/TSP based on clinical course and laboratory findings2011
Author(s)
Yamano Y., Sato T., Araya N., Yagishita N., Shimizu Y., Ando H., Utsunomiya A., Izumo S., Jacobson S., Suzuki N
Organizer
15th International Conference on Human Retrovirology : HTLV and Related Viruses
Place of Presentation
Leuven, Belgium(Aula Pieter De Somer)
Year and Date
2011-06-05
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