2011 Fiscal Year Final Research Report
The role of neuroinflammation and responsible molecules in Alzheimer's disease onset
| Project/Area Number |
22790835
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | National Institute of Radiological Sciences |
|---|
Principal Investigator |
JI Bin 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (80392223)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | MCP-1 / Gila / TSPO / TSPO ligand / Alzheimer's disease |
|---|
| Research Abstract |
The present study have investigated the feasibility of anti-neuroinflammation therapy by positron emission tomography(PET) with amyloid and neuroinflammation tracers in Alzheimer's disease(AD). Here, an anti-MCP-1(Monocyte Chemotactic Protein-1) antibody was applied to anti-amyloid immunotherapy to verify whether anti-MCP-1 therapy is able to increase the therapeutic effect and attenuate the side-effect of anti-amyloid therapy. As results, co-administration of anti-MCP-1 and anti-A. antibodies have greatly increased the effect of anti-amyloid therapy and attenuated the occurrence of neuroinflammation compared the therapy with anti-A. antibody only in AD model APP23 mice expressing amyloid pathology.
|
-
[Journal Article] Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology2012
Author(s)
Higuchi, M., Iwata, N., Matsuba, Y., Takano, J., Suemoto, T., Maeda, J., Ji, B., Ono, M., SPS19fenbiel, M., Suhara, T., and Saido, T.
-
Journal Title
FASEB J
Volume: 26
Pages: 1204-1217
DOI
-
[Journal Article] An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys : in vivo positron emission tomography imaging of glial activation2012
Author(s)
Shimazawa, M., Ito, Y., Inokuchi, Y., Yamanaka, H., Nakanishi, T., Hayashi, T., Ji, B., Higuchi, M., Suhara, T., Imamura, K., Araie, M., Watanabe, Y., Onoe, H., and Hara, H.
-
Journal Title
PLoS One
Volume: 7
Pages: e30526
DOI
-
[Journal Article] PET Applications in Animal Models of Neurodegenerative and Neuroinflammatory Disorders2011
Author(s)
Higuchi, M., Maeda, J., Ji, B., Tokunaga, M., Zhang, M. R., Maruyama, M., Ono, M., Fukumura, T., and Suhara, T
-
Journal Title
DOI
-
[Journal Article] In vivo positron emission tomographic imaging of glial responses to amyloid-beta and PS19 pathologies in mouse models of Alzheimer's disease and related disorders2011
Author(s)
Maeda, J., Zhang, M. R., Okauchi, T., Ji, B., Ono, M., Hattori, S., Kumata, K., Iwata, N., Saido, T. C., Trojanowski, J. Q., Lee, V. M., SPS19fenbiel, M., Tomiyama, T., Mori, H., Fukumura, T., Suhara, T., and Higuchi, M
-
Journal Title
J Neurosci
Volume: 31
Pages: 4720-4730
DOI
-
-
-
[Journal Article] In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis : Insights from neuroimaging research in humans and rodent models2010
Author(s)
Higuchi, M., Maeda, J., Ji, B., Maruyama, M., Okauchi, T., Tokunaga, M., Ono, M., and Suhara, T
-
Journal Title
Biochim Biophys Acta
Volume: 1802
Pages: 373-388
DOI
-
-
-
