2011 Fiscal Year Final Research Report
The role of proton-sensing G protein coupled receptor in bone remodeling
| Project/Area Number |
22790844
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
MOGI Chihiro 群馬大学, 生体調節研究所, 助教 (00375528)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 細胞・組織 / シグナル伝達 / 生理活性 / 生理学 / 生体分子 / 骨代謝 |
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| Research Abstract |
It is well known that extracellular pH plays important roles in bone remodeling, but the molecular mechanisms are yet unidentified. To reveal the roles of novel four proton-sensing receptors (OGR1, GPR4, TDAG8, G2A), we assessed the bone mineral density and histology in pH-receptor knockout mice. These results suggested the relationship between OGR1 family and bone metabolism.
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[Journal Article] Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo2012
Author(s)
Komachi M, Sato K, Tobo M, Mogi C, Yamada T, Ohta H, Tomura H, Kimura T, Im DS, Yanagida K, Ishii S, Takeyoshi I, Okajima F.
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Journal Title
Cancer Sci
Volume: in press
Peer Reviewed
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[Journal Article] Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells2011
Author(s)
Matsuzaki S, Ishizuka T, Yamada H, Kamide Y, Hisada T, Ichimonji I, Aoki H, Yatomi M, Komachi M, Tsurumaki H, Ono A, Koga Y, Dobashi K, Mogi C, Sato K, Tomura H, Mori M, Okajima F.
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Journal Title
Biochem Biophys Res Commun
Volume: 413(4)
Pages: 499-503
Peer Reviewed
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[Journal Article] protein-coupled receptor 1-dependent and-independent vascular actions to acidic pH in human aortic smooth muscle cells2010
Author(s)
Liu JP, Komachi M, Tomura H, Mogi C, Damirin A, Tobo M, Takano M, Nochi H, Tamoto K, Sato K, Okajima F. Ovarian cancer G
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 299(3)
Pages: H731-42
Peer Reviewed
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[Journal Article] Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways2010
Author(s)
Liu JP, Nakakura T, Tomura H, Tobo M, Mogi C, Wang JQ, He XD, Takano M, Damirin A, Komachi M, Sato K, Okajima F.
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Journal Title
Pharmacol Res
Volume: 61(6)
Pages: sa499-505
Peer Reviewed
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