2011 Fiscal Year Final Research Report
Exploring novel genes that regulate glycolysis using a genome-wide siRNA library
| Project/Area Number |
22790846
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 解糖系 / siRNAライブラリー / 癌細胞 / マクロファージ |
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| Research Abstract |
Glycolysis is a system of energy production which plays an important role in many diseases such as cancer and inflammatory diseases. However, how glycolysis is regulated remains unclear. To address this, we explored novel genes that regulate glycolysis using a genome-wide siRNA library, and identified novel 19 genes. Some of these genes regulate cancer cell growth or macrophage function. Therefore, these genes we identified in this study might be therapeutic targets for cancer or inflammatory diseases.
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