2011 Fiscal Year Final Research Report
Analysis of the physiological roles of PHF2/ARID5B, a novel fasting-responsive transcription complex
| Project/Area Number |
22790848
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKUNO Yosuke 東京大学, 分子細胞生物学研究所, 特任研究員 (10534513)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 転写 |
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| Research Abstract |
To elucidate the role of PHF2 in vivo, we have generated systemic PHF2 knockout mice. These mice had less adipose tissue compared to their littermates. Adipose tissue in these mice had decreased size and number of adipocytes. With in vitro study using primary cells from tamoxifen-inducible PHF2 KO, we have clarified that PHF2 promotes differentiation of adipocytes. This seemed to be through coactivation of C/EBPα.
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