2011 Fiscal Year Final Research Report
Impact of feeding-induced hepatic endoplasmic reticulum stress on insulin sensitivity
| Project/Area Number |
22790851
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 糖尿病 / 肝臓 / 摂食 / 小胞体ストレス / インスリンシグナル |
|---|
| Research Abstract |
Feeding physiologically induces hepatic endoplasmic reticulum(ER) stress, and the induction is mainly attributed to insulin signaling and protein intake. Sdf2l1, a novel ER stress modulator which we have focused on, is regulated at the level of transcription by ATF6 and XBP1, both in vitro and in vivo. We have been producing mice with Sdf2l1 ablated in a liver-specific manner, and already succeeded in obtaining hetero-knockout mice.
|
