2011 Fiscal Year Final Research Report
Association of insulin sensitivity and adipose tissue macrophages
| Project/Area Number |
22790853
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 肥満 / 脂肪組織 / インスリン抵抗性 / マクロファージ |
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| Research Abstract |
In obese adipose tissues, the number of inflammatory M1 macrophage is dramatically increased and the ratio of antiinflammatory M2 macrophage is reduced, resulting the decrease of insulin sensitivity and development of obesity complications. In this study, I found that telmisartan, an angiotensin II type I receptor blocker, improved insulin resistance with its PPARγactivity, by modulating M1/M2 macrophage ratio(Endocrinology, 152 : 1789-1799, 2011). I also found that obesity-induced hypoxia in adipose tissue is involved in M1 polarization of macrophages.
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[Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation2012
Author(s)
Watanabe Y., Nakamura T., Ishikawa S., Fujisaka S., Usui I., Tsuneyama K., Ichihara Y., Wada T., Hirata Y., Suganami T., Izaki H., Akira S., Miyake K., Kanayama H., Shimabukuro M., Sata M., Sasaoka T., Ogawa Y., Tobe K., Takatsu K., and Nagai Y
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Journal Title
Peer Reviewed
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[Journal Article] Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice2011
Author(s)
Fujisaka S., Usui I., Kanatani Y., Ikutani M., Takasaki I., Tsuneyama K., Tabuchi Y., Bukhari A., Yamazaki Y., Suzuki H., Senda S., Aminuddin A., Nagai Y., Takatsu K., Kobayashi M., Tobe K.
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Journal Title
Endocrinology 2011
Volume: 152-5
Pages: 1789-99
Peer Reviewed
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[Journal Article] Deletion of platelet-derived growth factor receptor-βimproves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase IIα(Thr286 Asp) transgenic mice2011
Author(s)
Suzuki H., Usui I., Kato I., Oya T., Kanatani Y., Yamazaki Y., Fujisaka S., Senda S., Ishii Y., Urakaze M., Mahmood A., Takasawa S., Okamoto H., Kobayashi M., Tobe K., Sasahara M.
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Journal Title
Diabetologia 2011
Volume: 54
Pages: 2953-2962
Peer Reviewed
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