2012 Fiscal Year Final Research Report
To elucidate the mechanism by which excessive intake of monosaccharide impairs glucose tolerance and the role of incretin
| Project/Area Number |
22790855
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Nagoya University |
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Principal Investigator |
SEINO Yusuke 名古屋大学, 医学系研究科, 寄附講座助教 (80534833)
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| Project Period (FY) |
2010 – 2012
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| Keywords | インクレチン / グルコキナーゼ / スクロース / 耐糖能障害 |
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| Research Abstract |
C57BL/6J mice received a control diet (CD), a 38.5% sucrose diet (HSD) or high-starch diet (CS) for 5 weeks. An oral glucose tolerance test (OGTT) showed that plasma glucose levels in the early phase were higher in HSD group than in other groups. The OGTT also showed no differences in blood glucose levels at baseline and 60 min among three groups. Mice fed HSD showed that glucagon-like peptide-1 secretion (GLP-1) was impaired, and that insulin secretion was relatively reduced. Hepatic glucokinase activity was significantly reduced and the accumulation of glycogen in the liver was suppressed during OGTT in HSD group. We therefore demonstrate reduction in hepatic glucokinase activity and impairment in GLP-1 secretion contributes to the glucose intolerance by excessive ingestion of monosaccharide.
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[Journal Article] Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion2012
Author(s)
Sakamoto E*, Seino Y*, Fukami A, Mizutani N, Tsunekawa S, Ishikawa K, Ogata H, Uenishi E, Kamiya H, Hamada Y, Sato H, Harada N, Toyoda Y, Miwa I, Nakamura J, Inagaki N, Oiso Y, Ozaki N
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Journal Title
contributed equally to this work Journal of Diabetes Investigation
Volume: 3
Pages: 432-440
Peer Reviewed
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