Role of gastric inhibitory polypeptide in modifying pancreatic islet function

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790857
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Kyoto University
• Principal Investigator: HAMASAKI Akihiro 京都大学, 大学院・医学研究科, 助教 (40456900)
• Project Period (FY): 2010 – 2011
• Keywords: インクレチン / GIP / 膵内分泌細胞 / グルカゴン / 糖尿病 / 肥満

Research Abstract

We generated gastric inhibitory polypeptide(GIP) receptor conditional knockout mice, and obtained pancreatic beta-cell specific GIP receptor knockout mice. These models enable us to investigate the roles of GIP on pancreatic islet endocrine cells in obesity and diabetes directly.

Research Products

• [Journal Article] Effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance (2012)
  • Author(s): Yamane, S., Harada, N., Hamasaki, A., Muraoka, A., Joo, E., Suzuki, K., Nasteska, D, Tanaka, D., Ogura, M., Harashima, S., Inagaki, N.
  • Journal Title: Journal of Diabetes Investigation Volume: vol3 Pages: 80-85
  • DOI: DOI:10.1111/j.2040-1124.2011.00143.x
  • Peer Reviewed
• [Journal Article] Analysis of factors influencing postprandial C-peptide levels in Japanese patients with type 2 diabetes : Comparison with C-peptide levels after glucagon load (2011)
  • Author(s): Funakoshi, S., Fujimoto, S., Hamasaki, A., Fujiwara, H., Fujita, Y, Ikeda, K., Takahara, S., Seino, Y, Inagaki, N.
  • Journal Title: Journal of Diabetes Investigation Volume: vol2 Pages: 429-434
  • DOI: DOI:10.1111/j.2040-1124.2011.00126.x
  • Peer Reviewed
• [Journal Article] Plasma gastric inhibitory polypeptide amd glucagon-like peptide-1 levels after glucose loading are associated with different factors in Japanese subjects (2011)
  • Author(s): Harada, N., Hamaski, A., Yamane, S., Muraoka, A., Joo, E., Fujita, K., Inagaki, N.
  • Journal Title: Journal of Diabetes Investigation Volume: vol2 Pages: 186-192
  • DOI: DOI:10.1111/j.2040-1124.2010.00078.x
  • Peer Reviewed
• [Presentation] GIPの基礎と臨床 (2011)
  • Author(s): 濱崎暁洋、原田範雄、山根俊介、稲垣暢也
  • Organizer: 日本糖尿病学会近畿地方会(シンポジウム)
  • Year and Date: 2011-10-29
• [Presentation] Effects of inhibited GIP secretion on high fat diet-induced obesity and insulin secretion (2011)
  • Author(s): Nasteska, D. Harada, N., Hamasaki, A., Inagaki, N., et al.
  • Organizer: Annual Meeting of the European Society for the Study of Diabetes
  • Place of Presentation: EASD
  • Year and Date: 2011-09-13
• [Presentation] Not glucose tolerance but obesity impairs the numerical incretin effect in Japanese subjects (2011)
  • Author(s): Hamasaki, A., Harada, N., Muraoka, A., Inagaki, N., et al.
  • Organizer: Annual Meeting of the European Society for the Study of Diabetes
  • Place of Presentation: EASD
  • Year and Date: 2011-09-13
• [Remarks]
  • URL: http://metab-kyoto-u.jp/