2011 Fiscal Year Final Research Report
Identification and the functional analysis of FGF15/19-βKlotho system andβKlotho-associated protein complex in adipocytes
| Project/Area Number |
22790859
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | 公益財団法人先端医療振興財団 (2011)
Kyoto University (2010) |
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Principal Investigator |
TANAKA Tomohiro 公益財団法人先端医療振興財団, 先端医療センター, 主任研究員 (20402894)
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| Project Period (FY) |
2010 – 2011
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| Keywords | プロテオーム / 脂肪細胞科学 / シグナル伝達 / エネルギー代謝 / メタボリックシンドローム |
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| Research Abstract |
βKlotho is a membrane protein highly expressed in the liver, exocrine pancreas, and adipose tissue. We have previously shown thatβKlotho is essential for FGF15/19 dependent negative feedback of bile acid synthesis from cholesterol. In this study, we find a potential role of FGF15/19-βKlotho system in the secretion of lipase and other pancreatic enzymes. We furthermore identified and confirmed twoβKlotho-binding transporters in white adipose tissue. Along withβKlotho, these membrane transporters are present and active in 3T3-L1 adipocytes, suggesting a role ofβKlotho in the regulation of transporter activity in adipocytes.
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Research Products
(15 results)
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[Journal Article] Decreased renal alpha-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion2012
Author(s)
O. Asai, K. Nakatani, T. Tanaka, H. Sakan, A. Imura, S. Yoshimoto, K. I. Samejima, Y. Yamaguchi, M. Matsui, Y. Akai, N. Konishi, M. Iwano, Y. Nabeshima, Y. Saito
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Journal Title
Kidney Int
Volume: 81(6)
Pages: 539-547
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[Journal Article] Relevant use of Klotho in FGF19 subfamily signaling in vivo2010
Author(s)
K. Tomiyama, R. Maeda, I. Urakawa, Y. Yamazaki, T. Tanaka, S. Ito, Y. Nabeshima, T. Tomita, S. Odori, K. Hosoda, K. Nakao, A. Imura, Y. Nabeshima
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Journal Title
Proc. Natl. Acad. Sci. U. S. A.
Volume: 107(4)
Pages: 1666-1671
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[Journal Article] Adipose tissue-specific regulation of angiotensinogen in obese humans and mice : Impact of nutritional status and adipocyte hypertrophy2010
Author(s)
S. Yasue, H. Masuzaki, S. Okada, T. Ishii, C. Kozuka, T. Tanaka, J. Fujikura, K. Ebihara, K. Hosoda, A. Katsurada, N. Ohashi, M. Urushihara, H. Kobori, N. Morimoto, T. Kawazoe, M. Naitoh, M. Okada, H. Sakaue, S. Suzuki, K. Nakao
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Journal Title
Am. J. Hypertens
Volume: 23(4)
Pages: 425-431
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[Journal Article] Adipose-tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity2010
Author(s)
S. Okada, C. Kozuka, H. Masuzaki, S. Yasue, T. Ishii-Yonemoto, T. Tanaka, Y. Yamamoto, M. Noguchi, T. Kusakabe, T. Tomita, J. Fujikura, K. Ebihara, K. Hosoda, H. Sakaue, H. Kobori, M. Ham, Y. S. Lee, J. B. Kim, Y. Saito, K. Nakao
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Journal Title
Metabolism
Volume: 59(9)
Pages: 1241-51
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[Journal Article] Glucocorticoid reamplification within cells intensifies NFkB and MAPK signaling and reinforces inflammation in activated preadipocytes2010
Author(s)
T. Ishii-Yonemoto, H. Masuzaki, S. Yasue, S. Okada, C. Kozuka, T. Tanaka, M. Noguchi, T. Tomita, J. Fujikura, Y. Yamamoto, K. Ebihara, K. Hosoda, K. Nakao
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Journal Title
Am. J. Physiol
Volume: 298(5)
Pages: E930-E940
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