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2011 Fiscal Year Final Research Report

Identification and the functional analysis of FGF15/19-βKlotho system andβKlotho-associated protein complex in adipocytes

Research Project

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Project/Area Number 22790859
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research Institution公益財団法人先端医療振興財団 (2011)
Kyoto University (2010)

Principal Investigator

TANAKA Tomohiro  公益財団法人先端医療振興財団, 先端医療センター, 主任研究員 (20402894)

Project Period (FY) 2010 – 2011
Keywordsプロテオーム / 脂肪細胞科学 / シグナル伝達 / エネルギー代謝 / メタボリックシンドローム
Research Abstract

βKlotho is a membrane protein highly expressed in the liver, exocrine pancreas, and adipose tissue. We have previously shown thatβKlotho is essential for FGF15/19 dependent negative feedback of bile acid synthesis from cholesterol. In this study, we find a potential role of FGF15/19-βKlotho system in the secretion of lipase and other pancreatic enzymes. We furthermore identified and confirmed twoβKlotho-binding transporters in white adipose tissue. Along withβKlotho, these membrane transporters are present and active in 3T3-L1 adipocytes, suggesting a role ofβKlotho in the regulation of transporter activity in adipocytes.

  • Research Products

    (15 results)

All 2012 2011 2010 2009

All Journal Article (9 results) Presentation (6 results)

  • [Journal Article] Decreased renal alpha-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion2012

    • Author(s)
      O. Asai, K. Nakatani, T. Tanaka, H. Sakan, A. Imura, S. Yoshimoto, K. I. Samejima, Y. Yamaguchi, M. Matsui, Y. Akai, N. Konishi, M. Iwano, Y. Nabeshima, Y. Saito
    • Journal Title

      Kidney Int

      Volume: 81(6) Pages: 539-547

  • [Journal Article] 心腎連関解明の新しい分子標的α2012

    • Author(s)
      田中智洋,鍋島陽一
    • Journal Title

      Klotho Cardiovascular Frontier

      Volume: Vol.3No.1 Pages: 30-37

  • [Journal Article] Relevant use of Klotho in FGF19 subfamily signaling in vivo2010

    • Author(s)
      K. Tomiyama, R. Maeda, I. Urakawa, Y. Yamazaki, T. Tanaka, S. Ito, Y. Nabeshima, T. Tomita, S. Odori, K. Hosoda, K. Nakao, A. Imura, Y. Nabeshima
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A.

      Volume: 107(4) Pages: 1666-1671

  • [Journal Article] Adipose tissue-specific regulation of angiotensinogen in obese humans and mice : Impact of nutritional status and adipocyte hypertrophy2010

    • Author(s)
      S. Yasue, H. Masuzaki, S. Okada, T. Ishii, C. Kozuka, T. Tanaka, J. Fujikura, K. Ebihara, K. Hosoda, A. Katsurada, N. Ohashi, M. Urushihara, H. Kobori, N. Morimoto, T. Kawazoe, M. Naitoh, M. Okada, H. Sakaue, S. Suzuki, K. Nakao
    • Journal Title

      Am. J. Hypertens

      Volume: 23(4) Pages: 425-431

  • [Journal Article] Adipose-tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity2010

    • Author(s)
      S. Okada, C. Kozuka, H. Masuzaki, S. Yasue, T. Ishii-Yonemoto, T. Tanaka, Y. Yamamoto, M. Noguchi, T. Kusakabe, T. Tomita, J. Fujikura, K. Ebihara, K. Hosoda, H. Sakaue, H. Kobori, M. Ham, Y. S. Lee, J. B. Kim, Y. Saito, K. Nakao
    • Journal Title

      Metabolism

      Volume: 59(9) Pages: 1241-51

  • [Journal Article] Glucocorticoid reamplification within cells intensifies NFkB and MAPK signaling and reinforces inflammation in activated preadipocytes2010

    • Author(s)
      T. Ishii-Yonemoto, H. Masuzaki, S. Yasue, S. Okada, C. Kozuka, T. Tanaka, M. Noguchi, T. Tomita, J. Fujikura, Y. Yamamoto, K. Ebihara, K. Hosoda, K. Nakao
    • Journal Title

      Am. J. Physiol

      Volume: 298(5) Pages: E930-E940

  • [Journal Article] メタボリック症候群と病理Klothoファミリ-による代謝の統合的制御2010

    • Author(s)
      田中智洋,鍋島陽一
    • Journal Title

      病理と臨床

      Volume: Vol.28 No.9 Pages: 924-931

  • [Journal Article] 「肥満症第2版-基礎・臨床研究の進歩」中枢メラノコルチン系(POMC/α-MSH)2010

    • Author(s)
      田中智洋、益崎裕章、中尾一和
    • Journal Title

      日本臨牀

      Volume: 68(Suppl. 2) Pages: 75-82

  • [Journal Article] メタボリックシンドロームのマスターレギュレーターとしてのPPARγ2009

    • Author(s)
      田中智洋、益崎裕章、細田公則、中尾一和
    • Journal Title

      日本臨牀

      Volume: 68 Pages: 203-209

  • [Presentation] 脂肪細胞は何を感じ、どう変化するのか-βクロトー分子の機能解析からのこころみ2012

    • Author(s)
      田中智洋
    • Organizer
      文部科学省特別経費プロジェクト学術講演会(招請講演)
    • Place of Presentation
      沖縄
    • Year and Date
      2012-02-09
  • [Presentation] βKlothoによる代謝制御の全貌解明を目指して2011

    • Author(s)
      田中智洋
    • Organizer
      第1回Metabolism Scientific Forum(口演)
    • Place of Presentation
      東京
    • Year and Date
      2011-12-23
  • [Presentation] βKlotho結合分子の同定と脂肪細胞機能制御における意義の探索2011

    • Author(s)
      田中智洋、小林加奈子、岡田定規、中川真美、鷲田美和、斎藤能彦、伊村明浩、鍋島陽一
    • Organizer
      第32回日本肥満学会(口演)
    • Place of Presentation
      淡路
    • Year and Date
      2011-09-23
  • [Presentation] クロトーの分子機能から明らかとなるカルシウム・脂質の新しい制御メカニズム2011

    • Author(s)
      田中智洋
    • Organizer
      第45回兵庫内分泌研究会(教育講演)
    • Place of Presentation
      神戸
    • Year and Date
      2011-07-16
  • [Presentation] 哺乳類個体の代謝制御におけるβKlothoの機能解明を目指して2011

    • Author(s)
      田中智洋、小林加奈子、鷲田美和、鍋島陽一
    • Organizer
      第29回日本内分泌学会内分泌代謝学サマーセミナー(ポスター)
    • Place of Presentation
      仙台
    • Year and Date
      2011-07-08
  • [Presentation] マウス視床下部CB1受容体発現調節における高脂肪食とニコチンの影響2010

    • Author(s)
      田中智洋、益崎裕章、泰江慎太郎、米本崇子、荒井直樹、冨田努、藤倉純二、海老原健、箕越靖彦、細田公則、中尾一和
    • Organizer
      第31回日本肥満学会(ポスター)
    • Place of Presentation
      前橋
    • Year and Date
      2010-10-01

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Published: 2013-07-31  

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