2012 Fiscal Year Final Research Report
The Role of Epac2 as a new target of sulfonylurea drugs
| Project/Area Number |
22790860
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Kobe University |
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Principal Investigator |
TAKAHASHI Harumi 神戸大学, 大学院・医学研究科, 学術推進研究員 (50546489)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 糖尿病 / インクレチン / スルホニル尿素薬 / インスリン分泌 / 膵β細胞 / cAMP |
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| Research Abstract |
Incretin/cAMP signaling and sulfonylurea synergistically augment insulin secretion from pancreatic β-cell. This interacting effect involves the enhancement of Epac2/Rap1 signaling and depends on the action of sulfonylureas on Epac2.
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Research Products
(24 results)
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[Journal Article] Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin2013
Author(s)
Asahara S, Shibutani Y, Teruyama K, Inoue HY, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y
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Journal Title
Diabetologia
Volume: 56
Pages: 1088-1097
DOI
Peer Reviewed
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[Journal Article] Rim2α determines docking and priming states in insulin granule exocytosis.2010
Author(s)
Yasuda T, Shibasaki T, Minami K, Takahashi H, Mizoguchi A, Uriu Y, Numata T, Mori Y, Miyazaki J-I, Miki T, Seino S
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Journal Title
Cell Metabolism
Volume: 12
Pages: 117-129
DOI
Peer Reviewed
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