2011 Fiscal Year Final Research Report

Effect of intrauterine undernutrition during late gestation on pancreatic beta cell mass.

Research Project

Project/Area Number	22790863
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Metabolomics
Research Institution	Kobe University
Principal Investigator	HASHIMOTO Naoko 神戸大学, 大学院・医学研究科, 特命助教 (40559845)
Project Period (FY)	2010 – 2011
Keywords	膵β細胞 / インスリンシグナル / 低出生体重
Research Abstract	We examined(1) the assay of the activity on insulin signaling in pancreatic. cells of the mice of food restriction group(RG), and(2) the roles of insulin signaling in pancreatic. cells during catch-up growth using pancreatic. cell-specific PDK1 deficient mouse. Pancreatic. cell mass at birth was decreased in RG offspring as compared to that in control offspring(CG). A high-fat diet significantly increased the pancreatic. cell mass in RG mice as compared to that in CG mice after birth. However, RG mice fed on high-fat diets tended to exhibit a decrease in the pancreatic. cell mass at approximately 24 weeks of age. The pancreatic. cell-specific PDK1 deficient mouse showed the inhibition of increase in pancreatic. cell mass during catch-up growth.