2011 Fiscal Year Final Research Report
The examination of oxidative stress and endoplasmic reticulum stress in diabetes mellitus.
| Project/Area Number |
22790873
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 酸化ストレス / 小胞体ストレス / インスリン抵抗性 / 臓器障害 |
|---|
| Research Abstract |
In diabetes, ASK-JNK pathway is considerably involved to oxidative stress and endoplasmic reticulum stress. So, we could think that this pathway was key pathway to improve insulin resistance. Moreover, to adjust this ASK-JNK pathway it can become a therapeutic target to type 2 diabetic patients, and it expects a possibility that this intervention will lead to prevention and slowly progression of diabetic complication in the future.
|
