2011 Fiscal Year Final Research Report

R oleofadipocyte-pcificmRNAregulatorysysteminthecontrol ofinsulin-mediatedglesucosemetabolism

Research Project

Project/Area Number	22790879
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Metabolomics
Research Institution	National Center for Geriatrics and Gerontology
Principal Investigator	SUGIMOTO Masataka 独立行政法人国立長寿医療研究センター, 老化細胞研究プロジェクトチーム, プロジェクトリーダー (50426491)
Project Period (FY)	2010 – 2011
Keywords	RNA結合タンパク質 / 脂肪細胞
Research Abstract	Adipocytes play essential roles in controlling the insulin sensitivity. We have previously shown that an RNA-binding protein Hzf is specifically expressed inadipose tissue and required for proper adipocyte functions thereby contributing to theregulation of insulin-mediated glucose metabolism. We here investigate the detailed molecular mechanism by which Hzf functions in adipocytes and show that Hzf associateswith another RNA-binding protein HuR. These proteins cooperate in the regulation of geneexpression through post-transcriptional mechanism, which is required for the adipocytefunctions.